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新型冠状病毒肺炎(COVID-19)的最佳封锁强度

The optimal lockdown intensity for COVID-19.

作者信息

Caulkins Jonathan P, Grass Dieter, Feichtinger Gustav, Hartl Richard F, Kort Peter M, Prskawetz Alexia, Seidl Andrea, Wrzaczek Stefan

机构信息

Heinz College, Carnegie Mellon University, 4800 Forbes Avenue, Pittsburgh PA 15213, USA.

International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361 Laxenburg, Austria.

出版信息

J Math Econ. 2021 Mar;93:102489. doi: 10.1016/j.jmateco.2021.102489. Epub 2021 Feb 3.

DOI:10.1016/j.jmateco.2021.102489
PMID:33558783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7857053/
Abstract

One of the principal ways nations are responding to the COVID-19 pandemic is by locking down portions of their economies to reduce infectious spread. This is expensive in terms of lost jobs, lost economic productivity, and lost freedoms. So it is of interest to ask: What is the optimal intensity with which to lockdown, and how should that intensity vary dynamically over the course of an epidemic? This paper explores such questions with an optimal control model that recognizes the particular risks when infection rates surge beyond the healthcare system's capacity to deliver appropriate care. The analysis shows that four broad strategies emerge, ranging from brief lockdowns that only "smooth the curve" to sustained lockdowns that prevent infections from spiking beyond the healthcare system's capacity. Within this model, it can be optimal to have two separate periods of locking down, so returning to a lockdown after initial restrictions have been lifted is not necessarily a sign of failure. Relatively small changes in judgments about how to balance health and economic harms can alter dramatically which strategy prevails. Indeed, there are constellations of parameters for which two or even three of these distinct strategies can all perform equally well for the same set of initial conditions; these correspond to so-called triple Skiba points. The performance of trajectories can be highly nonlinear in the state variables, such that for various times , the optimal unemployment rate could be low, medium, or high, but not anywhere in between. These complex dynamics emerge naturally from modeling the COVID-19 epidemic and suggest a degree of humility in policy debates. Even people who share a common understanding of the problem's economics and epidemiology can prefer dramatically different policies. Conversely, favoring very different policies is not evident that there are fundamental disagreements.

摘要

各国应对新冠疫情的主要方式之一是对部分经济活动实施封锁,以减少病毒传播。这在就业机会丧失、经济生产力损失和自由受限方面代价高昂。因此,人们不禁要问:封锁的最佳强度是多少,以及在疫情过程中这种强度应如何动态变化?本文通过一个最优控制模型来探讨这些问题,该模型认识到感染率飙升至医疗系统无法提供适当护理时的特殊风险。分析表明出现了四种广泛的策略,从仅“平缓曲线”的短暂封锁到防止感染飙升至医疗系统能力之上的持续封锁。在这个模型中,分两个不同阶段进行封锁可能是最优的,所以在最初的限制解除后再次实施封锁不一定是失败的迹象。在如何平衡健康和经济危害的判断上相对较小的变化,可能会极大地改变哪种策略占上风。实际上,存在这样一些参数组合,对于同一组初始条件,这两种甚至三种不同的策略都能表现得同样出色;这些对应于所谓的三重斯基巴点。轨迹的表现可能在状态变量上高度非线性,以至于在不同时间,最优失业率可能低、中或高,但不会处于两者之间的任何水平。这些复杂的动态变化自然地源于对新冠疫情的建模,并在政策辩论中体现出一定程度的谨慎。即使对问题的经济学和流行病学有共同理解的人,也可能倾向于截然不同的政策。相反,支持非常不同的政策并不一定表明存在根本性的分歧。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/2b983f99a37b/gr10_lrg.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/2b983f99a37b/gr10_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/c1d7ad1cb5be/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/e69beca5fc89/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/b5003616076e/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/871b657dfe42/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/0d7eb758d3f2/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/b21e114a8b4c/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/179d9fcd1d85/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/07ba163d2c72/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/43f981475268/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02be/7857053/2b983f99a37b/gr10_lrg.jpg

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