Karakter Child and Adolescent Psychiatry University Centre, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, P.O. Box 9104, 6500 HB, Nijmegen, The Netherlands.
J Autism Dev Disord. 2021 Dec;51(12):4506-4519. doi: 10.1007/s10803-021-04886-0. Epub 2021 Feb 9.
Pivotal Response Treatment (PRT) is promising for children with Autism Spectrum Disorder (ASD), but more methodologically robust designed studies are needed. In this randomized controlled trial, forty-four children with ASD, aged 9-15 years, were randomly allocated to PRT (n = 22) or treatment-as-usual (TAU; n = 22). Measurements were obtained after 12- and 20-weeks treatment, and 2-month follow-up. PRT resulted in significant greater improvements on parent-rated social-communicative skills after 12 weeks treatment (p = .004, partial η = 0.22), compared to TAU. Furthermore, larger gains in PRT compared to TAU were observed on blindly rated global functioning, and parent-rated adaptive socialization skills and attention problems. Implications for clinical practice and suggestions for future research are discussed.
关键反应治疗（PRT）对自闭症谱系障碍（ASD）儿童有希望，但需要更多设计更严谨的方法学研究。在这项随机对照试验中，将 44 名 9-15 岁的 ASD 儿童随机分为 PRT（n=22）或常规治疗（TAU；n=22）。在 12 周和 20 周治疗后和 2 个月随访时进行测量。与 TAU 相比，PRT 在 12 周治疗后，家长评定的社会交际技能显著改善（p=0.004，部分η=0.22）。此外，在盲法评定的整体功能、家长评定的适应社交技能和注意力问题方面，PRT 比 TAU 有更大的收益。讨论了对临床实践的影响和对未来研究的建议。
