Fan Shu-Xian, Zeng Peng, Li Zi-Jing, Wang Jing, Liang Jia-Qi, Liao Yun-Ru, Hu Yu-Xin, Xu Ming-Tong, Wang Mei
Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
J Ophthalmol. 2021 Jan 25;2021:9879503. doi: 10.1155/2021/9879503. eCollection 2021.
To investigate the clinical characteristics of Graves' orbitopathy (GO) with elevated intraocular pressure (IOP) using the European Group of Graves' Orbitopathy (EUGOGO) system.
In this retrospective study, the clinical data of GO patients with elevated IOP (≥21 mmHg) were collected in Sun Yat-sen Memorial Hospital from January 2010 to June 2016. The demographic characteristics, clinical history of thyroid disease and GO, and ocular examination data were evaluated, and the activity and severity of GO were classified.
Data were collected from 58 eyes of 39 patients. The durations of thyroid disease and GO were 15.9 ± 18.9 months and 7.5 ± 6.2 months, respectively. The average IOP was 24.8 ± 5.3 mmHg (range: 21-55 mmHg). No significant difference in IOP was observed between active and inactive eyes. Eight eyes (13.8%), 29 eyes (50.0%), and 21 eyes (36.2%) were graded as mild, moderate-severe, and sight-threatening disease, respectively, according to the EUGOGO classification. The IOP was not significantly different among the three EUGOGO grades. No glaucomatous optic nerve damage or visual field defects were found.
Increased IOP was evident for every grade of GO severity and activity of the EUGOGO system. IOP, glaucomatous optic nerve damage, and visual fields must be evaluated regularly during follow-up evaluations, regardless of the degree of activity and severity of GO.
采用欧洲Graves眼病（GO）研究组（EUGOGO）系统，调查眼压升高的Graves眼病（GO）的临床特征。
在这项回顾性研究中，收集了2010年1月至2016年6月在中山大学附属孙逸仙纪念医院就诊的眼压升高（≥21 mmHg）的GO患者的临床资料。评估患者的人口统计学特征、甲状腺疾病和GO的临床病史以及眼部检查数据，并对GO的活动度和严重程度进行分级。
收集了39例患者58只眼的数据。甲状腺疾病和GO的病程分别为15.9±18.9个月和7.5±6.2个月。平均眼压为24.8±5.3 mmHg（范围：21 - 55 mmHg）。活动期和非活动期眼之间眼压无显著差异。根据EUGOGO分级，8只眼（13.8%）、29只眼（50.0%）和21只眼（36.2%）分别被评为轻度、中度 - 重度和威胁视力疾病。三个EUGOGO分级之间眼压无显著差异。未发现青光眼性视神经损伤或视野缺损。
EUGOGO系统中，无论GO的活动度和严重程度如何，各等级的GO均有明显的眼压升高。在随访评估期间，必须定期评估眼压、青光眼性视神经损伤和视野情况。
