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阿托伐他汀诱导的难治性血小板减少症。

Atorvastatin-Induced Refractory Thrombocytopenia.

作者信息

Ghuman Jasmine, Manasewitsch Nicholas T, Ghuman Joban, Antwi-Amoabeng Daniel, Chahal Gurpreet

机构信息

Internal Medicine, University of Nevada, Reno School of Medicine, Reno, USA.

Internal Medicine, Dr. D. Y. Patil Medical College, Hospital & Research Centre, Pimpri, IND.

出版信息

Cureus. 2021 Jan 5;13(1):e12502. doi: 10.7759/cureus.12502.

DOI:10.7759/cureus.12502
PMID:33564510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7861060/
Abstract

Drug-induced thrombocytopenia is rarely associated with statin medications. We describe the case of a 69-year-old woman who developed refractory thrombocytopenia following atorvastatin use. To our knowledge, this is the fourth reported case of atorvastatin-induced thrombocytopenia and the first reported case of atorvastatin-induced refractory thrombocytopenia. Additionally, we summarize the cases of statin-induced thrombocytopenia reported in the medical literature.

摘要

药物性血小板减少症很少与他汀类药物相关。我们描述了一名69岁女性在使用阿托伐他汀后出现难治性血小板减少症的病例。据我们所知,这是第四例报道的阿托伐他汀诱导的血小板减少症病例,也是首例报道的阿托伐他汀诱导的难治性血小板减少症病例。此外,我们总结了医学文献中报道的他汀类药物诱导的血小板减少症病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/7861060/61574f5fbbc3/cureus-0013-00000012502-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/7861060/61574f5fbbc3/cureus-0013-00000012502-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66d4/7861060/61574f5fbbc3/cureus-0013-00000012502-i01.jpg

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Atorvastatin-Induced Refractory Thrombocytopenia.阿托伐他汀诱导的难治性血小板减少症。
Cureus. 2021 Jan 5;13(1):e12502. doi: 10.7759/cureus.12502.
2
Statin-Induced Thrombocytopenia in a Young Female: A Case Report and Literature Review.一名年轻女性的他汀类药物所致血小板减少症:病例报告及文献综述
Cureus. 2021 Nov 10;13(11):e19436. doi: 10.7759/cureus.19436. eCollection 2021 Nov.
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[Thrombocytopenia purpura, myositis and cytolitic hepatitis: a rare association linked with atorvastatin].
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Drug-Induced Immune Thrombocytopenia From Administration of a Local Anesthetic Agent Resulting in Splenectomy.因使用局部麻醉剂导致脾切除术的药物性免疫性血小板减少症。
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Drug-induced immune thrombocytopenia.药物性免疫性血小板减少症
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A rare case of factor X deficiency induced by valproic acid.丙戊酸诱发的罕见X因子缺乏症病例。
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Evaluation of the Effects of Atorvastatin and N-Acetyl Cysteine on Platelet Counts in Patients with Primary Immune Thrombocytopenia: An Exploratory Clinical Trial.阿托伐他汀和 N-乙酰半胱氨酸对原发性免疫性血小板减少症患者血小板计数影响的评价:一项探索性临床试验。
Medicina (Kaunas). 2023 Jun 11;59(6):1122. doi: 10.3390/medicina59061122.
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Statin-Induced Thrombocytopenia in a Young Female: A Case Report and Literature Review.

本文引用的文献

1
Prediction of pharmacokinetic drug-drug interactions causing atorvastatin-induced rhabdomyolysis using physiologically based pharmacokinetic modelling.基于生理的药代动力学模型预测阿托伐他汀引起横纹肌溶解的药物-药物相互作用的药代动力学。
Biomed Pharmacother. 2019 Nov;119:109416. doi: 10.1016/j.biopha.2019.109416. Epub 2019 Sep 10.
2
Statins in Stroke.他汀类药物在脑卒中中的应用。
Curr Med Chem. 2019;26(33):6174-6185. doi: 10.2174/0929867326666190620104539.
3
Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death.
一名年轻女性的他汀类药物所致血小板减少症:病例报告及文献综述
Cureus. 2021 Nov 10;13(11):e19436. doi: 10.7759/cureus.19436. eCollection 2021 Nov.
他汀类药物诱导的横纹肌溶解症、急性肾损伤和肝炎导致死亡。
Am J Case Rep. 2019 May 18;20:709-712. doi: 10.12659/AJCR.914707.
4
Improving the assessment of adverse drug reactions using the Naranjo Algorithm in daily practice: The Japan Adverse Drug Events Study.利用 Naranjo 算法在日常实践中改进药物不良反应评估:日本药物不良事件研究。
Pharmacol Res Perspect. 2018 Feb;6(1). doi: 10.1002/prp2.373.
5
Lovastatin induces platelet apoptosis.洛伐他汀诱导血小板凋亡。
Environ Toxicol Pharmacol. 2016 Mar;42:69-75. doi: 10.1016/j.etap.2016.01.002. Epub 2016 Jan 4.
6
Primary and Secondary Prevention of Acute Coronary Syndromes: The Role of the Statins.急性冠状动脉综合征的一级和二级预防:他汀类药物的作用
Recent Adv Cardiovasc Drug Discov. 2014;9(2):97-105. doi: 10.2174/1574890110666150708112349.
7
Simvastatin and amlodipine induced thrombocytopenia in the same patient: double trouble and a literature review.辛伐他汀和氨氯地平致同一患者血小板减少症:双重麻烦并文献复习。
J Clin Pharm Ther. 2013 Jun;38(3):246-8. doi: 10.1111/jcpt.12051. Epub 2013 Feb 26.
8
Atorvastatin-related thrombocytopenic purpura.阿托伐他汀相关的血小板减少性紫癜。
BMJ Case Rep. 2010 May 19;2010:bcr01.2010.2614. doi: 10.1136/bcr.01.2010.2614.
9
Long-term follow-up analysis after rituximab salvage therapy in adult patients with immune thrombocytopenia.利妥昔单抗挽救治疗成人免疫性血小板减少症的长期随访分析。
Am J Hematol. 2012 Sep;87(9):886-9. doi: 10.1002/ajh.23272. Epub 2012 Jun 20.
10
Rosuvastatin-induced thrombocytopenia.瑞舒伐他汀诱导的血小板减少症。
South Med J. 2010 Jul;103(7):676-8. doi: 10.1097/SMJ.0b013e3181e170f5.