Wang Fei, Gao Yuantao, Yuan Yitong, Du Ruochen, Li Pengfei, Liu Fang, Tian Ye, Wang Yali, Zhang Ruxin, Zhao Bichun, Wang Chunfang
Laboratory Animal Center, Shanxi Medical University, Taiyuan, China.
Nanchang University Queen Mary School, Nanchang, China.
Biomed Hub. 2020 Aug 5;5(2):93-104. doi: 10.1159/000508612. eCollection 2020 May-Aug.
In the past decades, the key roles of most microRNA in dermatosis and skin development have been explored one after another. Among them, microRNA-31 (miR-31) has a prominent role in the regulation of keratinocytes. Numerous studies show that miR-31 can positively regulate the proliferation, differentiation and cell activity of keratinocytes via regulating the NF-κB, RAS/MAPK, Notch signaling pathways, and some cytokines. At present, the interaction between miR-31 and the NF-κB signaling pathway in keratinocytes is a hot research topic. The positive feedback loop formed by miR-31 and NF-κB signaling may bring new ideas for the prevention of psoriasis. The abnormal state of keratinocytes is usually the pathological basis of many skin and immune system diseases. Therefore, strengthening the ability to regulate keratinocytes may be a breakthrough for a variety of diseases. At the same time, miR-31's capacity to accelerate wound healing via positively regulating keratinocytes should be further investigated in the treatment of chronic ulcers and trauma.
在过去几十年里，大多数微小RNA在皮肤病和皮肤发育中的关键作用已相继得到探索。其中，微小RNA-31（miR-31）在角质形成细胞的调控中发挥着重要作用。大量研究表明，miR-31可通过调节核因子κB（NF-κB）、RAS/丝裂原活化蛋白激酶（MAPK）、Notch信号通路以及一些细胞因子，正向调节角质形成细胞的增殖、分化和细胞活性。目前，miR-31与角质形成细胞中NF-κB信号通路之间的相互作用是一个热门研究课题。miR-31与NF-κB信号形成的正反馈环可能为银屑病的预防带来新思路。角质形成细胞的异常状态通常是许多皮肤和免疫系统疾病的病理基础。因此，增强调节角质形成细胞的能力可能是治疗多种疾病的一个突破点。同时，在慢性溃疡和创伤治疗中，应进一步研究miR-31通过正向调节角质形成细胞来加速伤口愈合的能力。
