Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Biomed Res Int. 2021 Jan 22;2021:8870425. doi: 10.1155/2021/8870425. eCollection 2021.
Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus Disease 2019 (COVID-19) infections are the three epidemiological diseases caused by the Coronaviridae family. Perceiving the immune responses in these infections and the escape of viruses could help us design drugs and vaccines for confronting these infections. This review investigates the innate and adaptive immune responses reported in the infections of the three coronaviruses SARS, MERS, and COVID-19. Moreover, the present study can trigger researchers to design and develop new vaccines and drugs based on immune system responses. In conclusion, due to the need for an effective and efficient immune stimulation against coronavirus, a combination of several strategies seems necessary for developing the vaccine.
严重急性呼吸综合征（SARS）、中东呼吸综合征（MERS）和 2019 年冠状病毒病（COVID-19）感染是由冠状病毒科引起的三种流行病学疾病。了解这些感染中的免疫反应和病毒的逃逸机制可以帮助我们设计药物和疫苗来对抗这些感染。本综述研究了 SARS、MERS 和 COVID-19 三种冠状病毒感染中报道的先天和适应性免疫反应。此外，本研究可以促使研究人员根据免疫系统反应设计和开发新的疫苗和药物。总之，由于需要针对冠状病毒进行有效和高效的免疫刺激，因此似乎需要结合几种策略来开发疫苗。
