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LncRNA SNHG1 在绝经后下调，并参与绝经后骨质疏松症。

LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis.

机构信息

Department of Orthopedics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou City 510080, Guangdong Province, P.R. China.

出版信息

Biosci Rep. 2019 Nov 29;39(11). doi: 10.1042/BSR20190445.

DOI:10.1042/BSR20190445
PMID:31693735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6851504/
Abstract

The functions of long (>200 nt) non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) have only been investigated in cancer biology. We found that plasma LncRNA SNHG1 was down-regulated in postmenopausal than in premenopausal females. Among postmenopausal females, the ones with postmenopausal osteoporosis showed much lower expression levels of plasma lncRNA SNHG1. A 6-year follow-up study on postmenopausal females revealed that plasma lncRNA SNHG1 decreased in females with postmenopausal osteoporosis but not in healthy postmenopausal females. Levels of plasma lncRNA SNHG1 at 12 months before diagnosis is sufficient to distinguish postmenopausal osteoporosis patients from healthy controls. After treatment, plasma lncRNA SNHG1 were significantly up-regulated. Therefore, lncRNA SNHG1 was down-regulated after menopause and plasma level of lncRNA SNHG1 may serve as a biomarker for the diagnosis and treatment of postmenopausal osteoporosis.

摘要

长 (>200nt) 非编码 RNA (lncRNA) 小核仁 RNA 宿主基因 1 (SNHG1) 的功能仅在癌症生物学中进行了研究。我们发现绝经后女性血浆 LncRNA SNHG1 水平下调，而在绝经前女性中则没有。在绝经后女性中，患有绝经后骨质疏松症的女性血浆 lncRNA SNHG1 表达水平明显更低。对绝经后女性进行的 6 年随访研究表明，血浆 lncRNA SNHG1 在患有绝经后骨质疏松症的女性中下降，但在健康的绝经后女性中没有下降。在诊断前 12 个月的血浆 lncRNA SNHG1 水平足以将绝经后骨质疏松症患者与健康对照组区分开来。经过治疗，血浆 lncRNA SNHG1 明显上调。因此，lncRNA SNHG1 在绝经后下调，血浆 lncRNA SNHG1 水平可能可作为绝经后骨质疏松症诊断和治疗的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/d50075753b0b/bsr-39-bsr20190445-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/ff9eaf13a15b/bsr-39-bsr20190445-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/c4434b92ab85/bsr-39-bsr20190445-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/30d58b740fa8/bsr-39-bsr20190445-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/d50075753b0b/bsr-39-bsr20190445-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/ff9eaf13a15b/bsr-39-bsr20190445-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/c4434b92ab85/bsr-39-bsr20190445-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/30d58b740fa8/bsr-39-bsr20190445-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b285/6851504/d50075753b0b/bsr-39-bsr20190445-g4.jpg

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