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Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.心输出量降低与认知正常的老年人的神经退行性变有关，但与轻度认知障碍无关。
Brain Imaging Behav. 2021 Aug;15(4):2040-2050. doi: 10.1007/s11682-020-00398-0. Epub 2020 Oct 10.
2
Management of low blood pressure in ambulatory heart failure with reduced ejection fraction patients.射血分数降低的门诊心力衰竭伴低血压患者的血压管理。
Eur J Heart Fail. 2020 Aug;22(8):1357-1365. doi: 10.1002/ejhf.1835. Epub 2020 Apr 30.
3
Lower Left Ventricular Ejection Fraction Relates to Cerebrospinal Fluid Biomarker Evidence of Neurodegeneration in Older Adults.左心室射血分数与老年人脑脊液生物标志物神经退行性变的关系。
J Alzheimers Dis. 2020;74(3):965-974. doi: 10.3233/JAD-190813.
4
The association between resting-state functional magnetic resonance imaging and aortic pulse-wave velocity in healthy adults.健康成年人静息态功能磁共振成像与主动脉脉搏波速度的相关性研究。
Hum Brain Mapp. 2020 Jun 1;41(8):2121-2135. doi: 10.1002/hbm.24934. Epub 2020 Feb 7.
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Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations.边缘为主型年龄相关性 TDP-43 脑病（LATE）：临床和神经病理学关联。
J Neuropathol Exp Neurol. 2020 Mar 1;79(3):305-313. doi: 10.1093/jnen/nlz126.
6
Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study.成年期血压与 1946 年英国出生队列神经科学子研究中晚年大脑结构和病理学的关联（Insight 46）：一项流行病学研究。
Lancet Neurol. 2019 Oct;18(10):942-952. doi: 10.1016/S1474-4422(19)30228-5. Epub 2019 Aug 20.
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Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia.中年至晚年血压模式与痴呆症发病的关联。
JAMA. 2019 Aug 13;322(6):535-545. doi: 10.1001/jama.2019.10575.
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Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.Twendee X 可改善慢性脑低灌注阿尔茨海默病转基因小鼠的磷酸化 tau、α-突触核蛋白和神经血管功能障碍。
J Stroke Cerebrovasc Dis. 2019 Oct;28(10):104310. doi: 10.1016/j.jstrokecerebrovasdis.2019.104310. Epub 2019 Aug 3.
9
Vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical Alzheimer's disease.血管危险因素与临床前阿尔茨海默病患者脑脊液 tau 标志物和认知的纵向变化有关。
Alzheimers Dement. 2019 Sep;15(9):1149-1159. doi: 10.1016/j.jalz.2019.04.015. Epub 2019 Aug 1.
10
Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.载脂蛋白E基因型改变老年人的心输出量与认知之间的关联。
J Am Heart Assoc. 2019 Aug 6;8(15):e011146. doi: 10.1161/JAHA.118.011146. Epub 2019 Jul 31.

心血管血流动力学对认知老化的影响。

Impact of Cardiovascular Hemodynamics on Cognitive Aging.

机构信息

Vanderbilt Memory & Alzheimer's Center (E.E.M., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.

Medical Scientist Training Program, School of Medicine, Vanderbilt University, Nashville, TN (E.E.M.).

出版信息

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1255-1264. doi: 10.1161/ATVBAHA.120.311909. Epub 2021 Feb 11.

DOI:10.1161/ATVBAHA.120.311909
PMID:33567862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7990698/
Abstract

[Figure: see text].

摘要

[图：见正文]。