Bantigen Kerebih, Kitaw Leul, Negeri Haweni, Kebede Mekonen, Wassie Addisu, Bishaw Keralem, Tesema Getaye
Nursing and Midwifery, Addis Ababa University, Addis Ababa, Ethiopia.
Midwifery, Welayita Sodo University, Welayita Sodo, Ethiopia.
HIV AIDS (Auckl). 2021 Feb 3;13:125-134. doi: 10.2147/HIV.S281281. eCollection 2021.
This study aimed to assess rate of HIV seroconversion and predictors among seronegative male partners living with HIV-positive women in Addis Ababa, Ethiopia, 2019.
Institutional-based retrospective cohort was used to conduct the study. All eligible 227 sample medical records were used for the study. Kaplan-Meier analysis was used to estimate seroconversion time. Cox proportional-hazard regression was used to identify predictor variables.
In this study, 227 seronegative male partners living with HIV-positive women were followed for 60 months retrospectively and 38 (16.7%) seroconversion was observed. The overall seroconversion rate was 6.4 (95%CI: 4.64-8.76) per 100 person-year observation. Time of antiretroviral therapy (ART) initiation, CD4 level, condom use, and having history of pregnancy after being diagnosed as discordant were identified significant predictors of seroconversion.
The risk of HIV transmission from seropositive partner to seronegative partner in a discordant couple is poorly controlled. Seronegative partners in discordant a couple can be seropositive at any time with influence of predictors unless proper protective measures, counseling, and follow-up are given emphasis.
本研究旨在评估2019年埃塞俄比亚亚的斯亚贝巴与HIV阳性女性共同生活的血清学阴性男性伴侣中的HIV血清转化发生率及预测因素。
采用基于机构的回顾性队列研究来开展此项研究。所有符合条件的227份样本病历用于该研究。采用Kaplan-Meier分析来估计血清转化时间。使用Cox比例风险回归来识别预测变量。
在本研究中，对227名与HIV阳性女性共同生活的血清学阴性男性伴侣进行了为期60个月的回顾性随访，观察到38例（16.7%）血清转化。总体血清转化率为每100人年观察期6.4例（95%置信区间：4.64 - 8.76）。开始抗逆转录病毒治疗（ART）的时间、CD4水平、避孕套使用情况以及被诊断为不一致后有怀孕史被确定为血清转化的显著预测因素。
在不一致的伴侣关系中，HIV从血清学阳性伴侣传播到血清学阴性伴侣的风险控制不佳。在不一致的伴侣关系中，血清学阴性伴侣在预测因素的影响下随时可能转为血清学阳性，除非重视适当的保护措施、咨询和随访。
