Department of Medical Ecology and Hydroclimatology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Rheumatol Int. 2021 Jul;41(7):1263-1271. doi: 10.1007/s00296-021-04882-8. Epub 2021 May 12.
To describe the rheumatic and musculoskeletal symptoms at hospitalization as well as their persistence/severity after discharge with coronavirus disease 2019 (COVID-19) and to identify whether age, sex, body mass index (BMI), and length of hospital stay are associated with persistence of these symptoms. In this single-center cohort study, comprising 300 participants, two phone interviews were conducted (2-week and 1-month after hospitalization) and symptoms were queried with a standardized form. This form included musculoskeletal symptoms and other COVID-19 symptoms. Considering all symptoms (musculoskeletal and other), 100.0%, 86.7%, and 72.0% of patients reported one or more symptoms, at hospitalization, 2-week, and 1-month, respectively. Considering only musculoskeletal symptoms, 92.3%, 72.7%, and 56.3% of patients reported any musculoskeletal symptom at hospitalization, 2-week, and 1-month, respectively. The musculoskeletal symptoms were fatigue (44.3% of patients reported), back pain (22.7%), arthralgia (22.0%), myalgia (21.0%), low back pain (16.3%), and neck pain (10.3%); the other symptoms were shortness of breath (26.3%), loss of taste (15.0%), cough (14.0%), loss of smell (12.3%), loss of appetite (10.3%), headache (8.7%), sore throat (3.0%), diarrhea (1.3%), dizziness (1.3%), and fever (0.3%) at 1-month. Increasing BMI was associated with higher odds of persistence of fatigue (OR: 1.08, 1.03 to 1.13), myalgia (OR: 1.08, 1.01 to 1.14), and arthralgia (OR: 1.07, 1.02 to 1.14, p = 0.012) at 1-month. Nearly three-quarters reported one or more symptoms, with more than half of patients reported any musculoskeletal symptom at 1 month. The most common musculoskeletal symptom was fatigue, followed by back pain, arthralgia, myalgia, low back pain, and neck pain. The persistence of fatigue, myalgia, and arthralgia was related to BMI. The study results increase our understanding of the spectrum of COVID-19, which, in turn, may lead to more efficient and better care for COVID-19 survivors.
描述新冠肺炎（COVID-19）住院患者的风湿和肌肉骨骼症状，以及出院后这些症状的持续存在/严重程度，并确定年龄、性别、体重指数（BMI）和住院时间是否与这些症状的持续存在有关。在这项单中心队列研究中，纳入了 300 名参与者，进行了两次电话访谈（住院后 2 周和 1 个月），并使用标准化表格询问了症状。该表格包括肌肉骨骼症状和其他 COVID-19 症状。考虑到所有症状（肌肉骨骼和其他），100.0%、86.7%和 72.0%的患者在住院时、2 周时和 1 个月时报告了一种或多种症状。仅考虑肌肉骨骼症状，92.3%、72.7%和 56.3%的患者在住院时、2 周时和 1 个月时分别报告有任何肌肉骨骼症状。肌肉骨骼症状为疲劳（44.3%的患者报告）、背痛（22.7%）、关节痛（22.0%）、肌痛（21.0%）、下腰痛（16.3%）和颈痛（10.3%）；其他症状为呼吸急促（26.3%）、味觉丧失（15.0%）、咳嗽（14.0%）、嗅觉丧失（12.3%）、食欲不振（10.3%）、头痛（8.7%）、喉咙痛（3.0%）、腹泻（1.3%）、头晕（1.3%）和发热（0.3%）。1 个月时，BMI 增加与疲劳（OR：1.08，1.03 至 1.13）、肌痛（OR：1.08，1.01 至 1.14）和关节痛（OR：1.07，1.02 至 1.14，p=0.012）持续存在的几率较高相关。近四分之三的患者报告了一种或多种症状，超过一半的患者在 1 个月时报告有任何肌肉骨骼症状。最常见的肌肉骨骼症状是疲劳，其次是背痛、关节痛、肌痛、下腰痛和颈痛。疲劳、肌痛和关节痛的持续存在与 BMI 有关。研究结果增加了我们对 COVID-19 谱的理解，这反过来又可能为 COVID-19 幸存者提供更有效和更好的护理。
