Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Dev Growth Differ. 2021 Feb;63(2):104-115. doi: 10.1111/dgd.12715. Epub 2021 Mar 22.
Forty years have passed since the first pluripotent stem cells (PSCs), mouse embryonic stem cells (ESCs), were established. Since then, several PSCs have been reported, including human ESCs in 1998, mouse epiblast stem cells (EpiSCs) in 2007, induced PSCs (iPSCs) in 2006 and 2007, and naïve human PSCs in 2014. Naïve PSCs are thought to correspond to pre-implantation epiblast cells, whereas conventional (or primed) human PSCs correspond to post-implantation epiblast cells. Thus, naïve and primed PSCs are classified by their developmental stages and have stage-specific characteristics, despite sharing the common feature of pluripotency. In this review, we discuss the current status of PSCs and their use to model human peri-implantation development.
自第一个多能干细胞（PSCs），即小鼠胚胎干细胞（ESCs）于 1975 年建立以来，已经过去了 40 年。此后，又有几种 PSCs 被报道，包括 1998 年的人类 ESCs、2007 年的小鼠上胚层干细胞（EpiSCs）、2006 年和 2007 年的诱导多能干细胞（iPSCs）以及 2014 年的原始人类 PSCs。原始 PSCs 被认为与着床前的上胚层细胞相对应，而传统（或初始）的人类 PSCs 则与着床后的上胚层细胞相对应。因此，原始和初始 PSCs 根据其发育阶段进行分类，尽管它们具有多能性的共同特征，但具有阶段特异性特征。在这篇综述中，我们讨论了 PSCs 的现状及其在模拟人类着床前发育中的应用。
