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人源凝集素、它们的碳水化合物亲和性以及它们的来源。

Human Lectins, Their Carbohydrate Affinities and Where to Find Them.

机构信息

LAQV-Requimte, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.

Glanbia-AgriChemWhey, Lisheen Mine, Killoran, Moyne, E41 R622 Tipperary, Ireland.

出版信息

Biomolecules. 2021 Jan 29;11(2):188. doi: 10.3390/biom11020188.

Abstract

Lectins are a class of proteins responsible for several biological roles such as cell-cell interactions, signaling pathways, and several innate immune responses against pathogens. Since lectins are able to bind to carbohydrates, they can be a viable target for targeted drug delivery systems. In fact, several lectins were approved by Food and Drug Administration for that purpose. Information about specific carbohydrate recognition by lectin receptors was gathered herein, plus the specific organs where those lectins can be found within the human body.

摘要

凝集素是一类负责多种生物学功能的蛋白质,如细胞-细胞相互作用、信号通路和几种针对病原体的固有免疫反应。由于凝集素能够与碳水化合物结合,因此它们可以成为靶向药物递送系统的可行目标。事实上,有几种凝集素已被食品和药物管理局批准用于此目的。本文收集了有关凝集素受体对特定碳水化合物识别的信息,以及这些凝集素在人体内可以找到的特定器官。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8489/7911577/d35c799fb6f5/biomolecules-11-00188-g001.jpg

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