Department of Zoology and Physiology, University of Wyoming, Laramie, WY, United States.
Front Neural Circuits. 2021 Oct 20;15:768571. doi: 10.3389/fncir.2021.768571. eCollection 2021.
Depression is an umbrella term used to describe a mood disorder with a broad spectrum of symptoms including a persistent feeling of sadness, loss of interest, and deficits in social behavior. Epigenetic research bridges the environmental and genetic landscape and has the potential to exponentially improve our understanding of such a complex disorder. Depression is also a sexually dimorphic disorder and variations exist within epigenetic modification sites between sexes. These sex-specific mediators may impact behavioral symptomology and could serve as therapeutic targets for treatments to improve behavioral deficits. This mini review will focus on the social behavior perspective of depression and specifically explore the sexually different epigenetic modifications on depression.
抑郁症是一个广义术语，用于描述一种具有广泛症状的情绪障碍，包括持续的悲伤感、失去兴趣和社交行为缺陷。表观遗传学研究架起了环境和遗传之间的桥梁，具有极大地提高我们对这种复杂疾病理解的潜力。抑郁症也是一种性别二态性疾病，在性别之间的表观遗传修饰部位存在差异。这些性别特异性的介质可能会影响行为症状，并可能成为改善行为缺陷的治疗靶点。本综述将重点关注抑郁症的社会行为方面，并特别探讨抑郁症的性别特异性的表观遗传修饰。
