铜配位络合物对植物细胞姐妹染色单体交换的影响。

Effect of copper coordination complexes on sister-chromatid exchanges in plant cells.

作者信息

Hazen M J, Juarranz A, Stockert J C, González A, Beltrán-Porter D

机构信息

Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.

出版信息

Mutat Res. 1988 Mar-Apr;207(3-4):135-9. doi: 10.1016/0165-7992(88)90077-2.

DOI:10.1016/0165-7992(88)90077-2

PMID:3357489

Abstract

The effectiveness of several copper coordination complexes in the induction of sister-chromatid exchanges (SCE) in meristematic cells of Allium cepa roots was studied. A significant increase in the frequencies of SCE was observed when cells were exposed to different concentrations of copper complexes for 3 h. This effect, which is concentration dependent, seems to be related to the possibility of intercalative binding modes between the planar copper complexes and DNA.

摘要

研究了几种铜配位络合物对洋葱根尖分生组织细胞中姐妹染色单体交换（SCE）的诱导作用。当细胞暴露于不同浓度的铜络合物中3小时后，观察到SCE频率显著增加。这种浓度依赖性效应似乎与平面铜络合物和DNA之间的嵌入结合模式的可能性有关。