Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
Department of Biological Sciences, University of California at San Diego, La Jolla, CA, USA.
EMBO J. 2021 Mar 1;40(5):e107651. doi: 10.15252/embj.2021107651. Epub 2021 Feb 11.
Defining the pulmonary cell types infected by SARS-CoV-2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID-19. Recent work establishing a human lung organoid-derived air-liquid interface model permissive to SARS-CoV-2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection-induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.
明确感染 SARS-CoV-2 的肺部细胞类型，并找到预防后续组织损伤的方法，是控制 COVID-19 的关键目标。最近的一项工作建立了一种人肺类器官衍生的气液界面模型，该模型允许 SARS-CoV-2 感染，确定肺泡 II 型细胞是主要感染的细胞类型，报告了一种感染诱导的干扰素反应，并证明了干扰素 lambda 1 治疗抑制肺部感染的有效性。
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