The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China.
Yunnan Health Cell Biotechnology LTD, Kunming 650031, China.
Cells. 2022 Sep 4;11(17):2758. doi: 10.3390/cells11172758.
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has severely affected socio-economic conditions and people's life. The lung is the major target organ infected and (seriously) damaged by SARS-CoV-2, so a comprehensive understanding of the virus and the mechanism of infection are the first choices to overcome COVID-19. Recent studies have demonstrated the enormous value of human organoids as platforms for virological research, making them an ideal tool for researching host-pathogen interactions. In this study, the various existing lung organoids and their identification biomarkers and applications are summarized. At the same time, the seven coronaviruses currently capable of infecting humans are outlined. Finally, a detailed summary of existing studies on SARS-CoV-2 using lung organoids is provided and includes pathogenesis, drug development, and precision treatment. This review highlights the value of lung organoids in studying SARS-CoV-2 infection, bringing hope that research will alleviate COVID-19-associated lung infections.
新型冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的一种全球大流行疾病，严重影响了社会经济状况和人们的生活。肺是 SARS-CoV-2 感染和（严重）损伤的主要靶器官，因此全面了解病毒和感染机制是克服 COVID-19 的首选。最近的研究表明，人类类器官作为病毒学研究平台具有巨大的价值，使其成为研究宿主-病原体相互作用的理想工具。在本研究中，总结了各种现有的肺类器官及其鉴定生物标志物和应用。同时，概述了目前能够感染人类的七种冠状病毒。最后，详细总结了使用肺类器官研究 SARS-CoV-2 的现有研究，包括发病机制、药物开发和精准治疗。本综述强调了肺类器官在研究 SARS-CoV-2 感染中的价值，为缓解 COVID-19 相关肺部感染带来了希望。
