Department of Dermatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Department of Dermatology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
J Dtsch Dermatol Ges. 2021 Apr;19(4):509-515. doi: 10.1111/ddg.14426. Epub 2021 Feb 12.
Acne is an androgen-dependent inflammatory disease of sebaceous follicles. Herein, we reviewed and discussed the underlying pathways of androgen biosynthesis and metabolism, non-genomic regulation of androgen receptor expression and function, posttranslational regulation of androgen excess in acne and acne-associated syndromes, such as polycystic ovary syndrome, and congenital adrenal hyperplasia. We provide insights into the involvement of sex hormones, particularly androgens, in skin homeostasis and acne pathogenesis, including comedogenesis, lipogenesis, microbiota, and inflammation. Advanced understanding of the action mechanisms of classical acne treatment and new development of antiandrogens, both topical and systemic, are also highlighted.
痤疮是一种皮脂毛囊的雄激素依赖性炎症性疾病。在此，我们综述并讨论了雄激素生物合成和代谢的潜在途径、雄激素受体表达和功能的非基因组调控、痤疮和相关综合征（如多囊卵巢综合征和先天性肾上腺增生症）中雄激素过多的翻译后调节。我们深入了解性激素（尤其是雄激素）在皮肤稳态和痤疮发病机制中的作用，包括粉刺形成、脂肪生成、微生物群和炎症。还强调了经典痤疮治疗作用机制的深入了解和新型抗雄激素药物（包括局部和全身制剂）的开发。
