School of Mechanical Engineering, Korea University, Seoul, 02841, Republic of Korea.
Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Adv Healthc Mater. 2021 May;10(9):e2002122. doi: 10.1002/adhm.202002122. Epub 2021 Feb 12.
Nanoparticles have an extensive range of diagnostic and therapeutic applications in cancer treatment. However, their current clinical translation is slow, mainly due to the failure to develop preclinical evaluation techniques that can draw similar conclusions to clinical outcomes by adequately mimicking nanoparticle behavior in complicated tumor microenvironments (TMEs). Microfluidic methods offer significant advantages over conventional in vitro methods to resolve these challenges by recapitulating physiological cues of the TME such as the extracellular matrix, shear stress, interstitial flow, soluble factors, oxygen, and nutrient gradients. The methods are capable of de-coupling microenvironmental features, spatiotemporal controlling of experimental sequences, and high throughput readouts in situ. This progress report highlights the recent achievements of microfluidic models to reconstitute the physiological microenvironment, especially for nanomedical tools for cancer treatment.
纳米颗粒在癌症治疗的诊断和治疗中有广泛的应用。然而，它们目前的临床转化速度较慢，主要是因为未能开发出临床前评估技术，这些技术能够通过充分模拟复杂肿瘤微环境 (TME) 中的纳米颗粒行为，得出与临床结果相似的结论。微流控方法相对于传统的体外方法具有显著优势，可通过再现 TME 的生理信号（如细胞外基质、切应力、间质流、可溶性因子、氧和营养梯度）来解决这些挑战。这些方法能够解耦微环境特征、时空控制实验序列以及原位高通量读取。本进展报告重点介绍了微流控模型在重建生理微环境方面的最新进展，特别是用于癌症治疗的纳米医学工具。
