School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
School of Agricultural Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Food Chem Toxicol. 2021 Apr;150:112054. doi: 10.1016/j.fct.2021.112054. Epub 2021 Feb 10.
To explore novel sources of anti-fatigue drugs and food, the anti-fatigue activity of hemp leaves water extract (HLWE) was investigated through exhaustive swimming tests of mice. The median exhaustion swimming time of mice gavaged with HLWE reached 55.4 min, which was 156.8% and 87.8% longer than that of the control group and Rhodiola group, respectively. Then, several biochemical parameters related to fatigue were determined to explore the possible anti-fatigue reasons. The blood lactic acid concentration of mice in HLWE group was 0.76 mmol/L, which was 24.8% lower than that in the control group. Compared with the control group, the glutathione peroxidases activity of mice in HLWE group increased by 296.2%. Based on the results, HLWE exhibited outstanding anti-fatigue activity through reducing the accumulation of lactic acid and improving the activities of defense antioxidant enzymes. It shows appealing potential for development and utilization as novel anti-fatigue food or drugs.
为了探索新型抗疲劳药物和食品的来源，本研究通过小鼠力竭游泳实验考察了大麻叶水提物（HLWE）的抗疲劳活性。灌胃 HLWE 的小鼠的中位力竭游泳时间达到 55.4 分钟，分别比对照组和红景天组延长了 156.8%和 87.8%。然后，测定了与疲劳相关的几种生化参数，以探讨其可能的抗疲劳机制。HLWE 组小鼠的血液乳酸浓度为 0.76mmol/L，比对照组低 24.8%。与对照组相比，HLWE 组小鼠的谷胱甘肽过氧化物酶活性增加了 296.2%。基于这些结果，HLWE 通过降低乳酸的积累和提高防御抗氧化酶的活性表现出优异的抗疲劳活性。它作为新型抗疲劳食品或药物具有诱人的开发利用潜力。
