Li Zhitong, Chen Zhaobo, Chen Xiongbiao, Zhao Runchao
School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, 150000, Heilongjiang, China.
School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, 150000, Heilongjiang, China.
J Mech Behav Biomed Mater. 2021 Apr;116:104332. doi: 10.1016/j.jmbbm.2021.104332. Epub 2021 Jan 20.
Scaffolds in tissue engineering can be created or printed nowadays with various structures that consist of a number of three-dimensional (3D) units stacked together periodically. The performance or properties of such scaffolds can be affected by the unit configurations and parameters, which, however, has not been well investigated and elucidated. This paper presents our study on the influence of unit configuration and parameters on the scaffolds performance by taking triply periodic minimal surfaces (TPMS) as the basic unit. The normalized values of elastic modulus, shear modulus and permeability were used to characterize the scaffold performance and analyzed by means of finite element analysis and CFD simulation, with focus on identifying the influence of unit configurations and parameters on the scaffold mechanical and permeable properties. Furthermore, by selective laser melting (SLM) printing technique, the cubic Primitive and IWP scaffolds with an oversize of 12 mm (2 × 2 × 2 units) were created and subjected to compressive tests. Both simulation and experiment results are in agreement to illustrate that unit configuration and parameters have significant influence on the mechanical and permeable properties of TPMS units. The methods and findings in the present work would serve as the base or rationales to regulate the unit configurations and parameters with trade-off solutions for given tissue engineering application.
如今，组织工程中的支架可以通过各种结构来制造或打印，这些结构由多个周期性堆叠在一起的三维（3D）单元组成。这种支架的性能或特性会受到单元配置和参数的影响，然而，这方面尚未得到充分的研究和阐明。本文以三重周期极小曲面（TPMS）为基本单元，介绍了我们对单元配置和参数对支架性能影响的研究。弹性模量、剪切模量和渗透率的归一化值用于表征支架性能，并通过有限元分析和CFD模拟进行分析，重点是确定单元配置和参数对支架力学和渗透性能的影响。此外，通过选择性激光熔化（SLM）打印技术，制作了尺寸为12毫米（2×2×2个单元）的立方原始和IWP支架，并进行了压缩试验。模拟和实验结果均表明，单元配置和参数对TPMS单元的力学和渗透性能有显著影响。本工作中的方法和发现将为在给定的组织工程应用中通过权衡解决方案来调节单元配置和参数提供依据。
