Chair of Urology and Andrology, Department of Regenerative Medicine, Cell and Tissue Bank, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Skłodowskiej-Curie 9, 85-094, Bydgoszcz, Poland.
Department of Plastic, Reconstructive and Aesthetic Surgery, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
Sci Rep. 2021 Feb 12;11(1):3775. doi: 10.1038/s41598-021-83128-w.
This study developed a new procedure of urinary bladder transplantation on a rat model (n = 40). Heterotopic urinary bladder transplantation (n = 10) in the right groin vessels was performed. Direct urinary bladder examination, microangiography, histological analysis, and India ink injection were performed to evaluate the proposed method's functionality. Observation time was four weeks. One week after the procedure, the graft survival rate was 80%, two urinary bladders were lost due to anastomosis failure. The rest of the grafts survived two weeks without any complications. Lack of transitional epithelium or smooth muscle layer loss and lack of inflammatory process development were observed. This study was performed in order to obtain the necessary knowledge about urinary bladder transplantation. The proposed technique offers a new approach to the existing orthotropic models.
本研究在大鼠模型上开发了一种新的膀胱移植程序（n=40）。在右侧腹股沟血管中进行了异位膀胱移植（n=10）。进行了直接膀胱检查、微血管造影、组织学分析和印度墨水注射，以评估所提出方法的功能。观察时间为四周。手术后一周，移植物存活率为 80%，由于吻合失败，丢失了两个膀胱。其余的移植物在没有任何并发症的情况下存活了两周。观察到没有过渡上皮或平滑肌层丢失，也没有炎症过程发展。进行这项研究是为了获得关于膀胱移植的必要知识。所提出的技术为现有的同种异体模型提供了一种新的方法。
