Rinaldi Fabio, Trink Anna, Giuliani Giammaria, Pinto Daniela
International Hair Research Foundation (IHRF), Milan, Italy.
Dermatol Ther (Heidelb). 2021 Apr;11(2):339-345. doi: 10.1007/s13555-021-00498-9. Epub 2021 Feb 12.
The inflammation storm involved in coronavirus disease 2019 (COVID-19) infection and worsening and the psychological stress derived from current quarantine conditions can affect the course of many skin and scalp conditions. This study examined the possible effects of COVID-19 on alopecia areata (AA) relapse in patients suffering from these scalp conditions during the pandemic.
The study was carried out in the form of an observational cross-sectional type using a questionnaire sent by mail to a cohort of patients affected by AA during the pandemic from March 2020 to October 2020.
During the pandemic, AA relapse was reported in 42.5% of the participants who also declared COVID-19 infection, confirmed by nasopharyngeal swab or hematological analysis. The relapse was reported about 2 months later COVID-19 infection (median of 2.14 months) and 74.0% of these participants continue to experience AA symptoms when the survey was proposed. Only 12.5% of participants reported AA relapse in the absence of COVID-19 infection.
The present study reported a significant relapse in patients suffering from AA and infected by COVID-19. This phenomenon could be attributed to the inflammation storm typical of COVID-19 infection and the psychological stress derived from quarantine conditions.
2019冠状病毒病（COVID-19）感染及病情恶化所引发的炎症风暴，以及当前隔离措施所带来的心理压力，可能会影响多种皮肤和头皮疾病的病程。本研究调查了COVID-19大流行期间，这些头皮疾病患者斑秃（AA）复发的可能影响因素。
本研究采用观察性横断面研究形式，通过邮件向2020年3月至2020年10月大流行期间受斑秃影响的一组患者发送问卷。
在大流行期间，42.5%的参与者报告斑秃复发，这些参与者还声明经鼻咽拭子或血液学分析确诊感染了COVID-19。斑秃复发报告时间约在COVID-19感染后2个月（中位数为2.14个月），在进行调查时，74.0%的这些参与者仍有斑秃症状。只有12.5%的参与者报告在未感染COVID-19的情况下斑秃复发。
本研究报告了感染COVID-19的斑秃患者出现显著复发。这一现象可能归因于COVID-19感染典型的炎症风暴以及隔离措施带来的心理压力。
