Centre for Ocean Research, MoES - Earth Science and Technology Cell (ESTC), Sathyabama Institute of Science and Technology, Chennai 600 119, India.
Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai 600 119, India.
Int J Biol Macromol. 2021 Apr 15;176:424-436. doi: 10.1016/j.ijbiomac.2021.02.074. Epub 2021 Feb 11.
Several research in the organisms of marine invertebrates to assess the medicinal ability of its bio-active molecules have yielded very positive results in recent times. Jellyfish secreted venoms are rich sources of toxins intended to catch prey or deter predators among invertebrate species, but they may also have harmful effects on humans. The nematocyst, a complex intracellular system that injects a venomous mixture into prey or predators that come into contact with the tentacles or other parts of the body of cnidarians, determines the venomous existence of cnidarians. Nematocyst venoms are mixtures of peptides, proteins and other components that in laboratory animals can induce cytotoxicity, blockade of ion channels, membrane pore formation, in vivo cardiovascular failure and lethal effects. There are also valuable pharmacological and biological aspects of jellyfish venoms. In the present review, overviews of the variety of possible toxin families in cnidarian venoms are addressed in this analysis and these potential toxins are surveyed with those from other cnidarians that offer insight into their potential functions such as anti-oxidant, anti-cancer activity and much more. This research review will provide awareness of the growing repertoire of jellyfish venom proteins and will help to further isolate and classify particular proteins to understand its structure and functional relationship.
近年来，对海洋无脊椎动物生物体的多项研究评估了其生物活性分子的药用能力，取得了非常积极的结果。水母分泌的毒液是毒素的丰富来源，旨在捕捉猎物或阻止无脊椎动物物种中的捕食者，但它们也可能对人类造成有害影响。刺丝囊，一种将有毒混合物注入接触刺细胞或其他身体部位的触手或其他身体部位的猎物或捕食者的复杂细胞内系统，决定了刺细胞动物的有毒存在。刺丝囊毒液是肽、蛋白质和其他成分的混合物，在实验动物中可以诱导细胞毒性、阻断离子通道、形成膜孔、体内心血管衰竭和致命作用。水母毒液还具有有价值的药理学和生物学方面。在本综述中，对刺细胞毒液中可能存在的多种毒素家族进行了概述，并对这些潜在的毒素进行了调查，与其他刺细胞动物的毒素进行了比较，从而深入了解它们的潜在功能，如抗氧化、抗癌活性等。这项研究综述将提高对不断增长的水母毒液蛋白库的认识，并有助于进一步分离和分类特定的蛋白质，以了解其结构和功能关系。
