Department of Animal Science, University of California, Davis, CA95616, USA.
Br J Nutr. 2021 Dec 14;126(11):1611-1625. doi: 10.1017/S0007114521000556. Epub 2021 Feb 15.
The intestinal tract is the entry gate for nutrients and symbiotic organisms, being in constant contact with external environment. DNA methylation is one of the keys to how environmental conditions, diet and nutritional status included, shape functionality in the gut and systemically. This review aims to summarise findings on the importance of methylation to gut development, differentiation and function. Evidence to date on how external factors such as diet, dietary supplements, nutritional status and microbiota modifications modulate intestinal function through DNA methylation is also presented.
肠道是营养物质和共生生物的进入门户，与外部环境不断接触。DNA 甲基化是环境条件、饮食和营养状况等如何影响肠道和全身功能的关键之一。本综述旨在总结甲基化对肠道发育、分化和功能的重要性。此外，还介绍了迄今为止关于饮食、膳食补充剂、营养状况和微生物组改变等外部因素如何通过 DNA 甲基化调节肠道功能的证据。
