Montgomery Leslie D, Montgomery Richard W, Gerth Wayne A, Bodo Michael, Stewart Julian M, Loughry Marty
LDM Associates, San Jose, USA.
Walter Reed Army Institute of Research, Silver Spring, MD, USA Current position: Tulane University School of Medicine, New Orleans, LA, USA.
J Electr Bioimpedance. 2019 Aug 20;10(1):40-46. doi: 10.2478/joeb-2019-0006. eCollection 2019 Jan.
This paper describes a new combined impedance plethysmographic (IPG) and electrical bioimpedance spectroscopic (BIS) instrument and software that will allow noninvasive real-time measurement of segmental blood flow, intracellular, interstitial, and intravascular volume changes during various fluid management procedures. The impedance device can be operated either as a fixed frequency IPG for the quantification of segmental blood flow and hemodynamics or as a multi-frequency BIS for the recording of intracellular and extracellular resistances at 40 discrete input frequencies. The extracellular volume is then deconvoluted to obtain its intravascular and interstitial component volumes as functions of elapsed time. The purpose of this paper is to describe this instrumentation and to demonstrate the information that can be obtained by using it to monitor segmental compartment volume responses of a pig model during simulated hemorrhage and resuscitation. Such information may prove valuable in the diagnosis and management of rapid changes in the body fluid balance and various clinical treatments.
本文介绍了一种新型的组合式阻抗体积描记法（IPG）和生物电阻抗光谱法（BIS）仪器及软件，该仪器和软件能够在各种液体管理程序期间对节段性血流、细胞内、间质和血管内容积变化进行无创实时测量。该阻抗设备既可以作为固定频率的IPG用于定量节段性血流和血流动力学，也可以作为多频率的BIS用于在40个离散输入频率下记录细胞内和细胞外电阻。然后对细胞外容积进行反褶积处理，以获得其血管内和间质成分容积随时间的变化函数。本文的目的是描述这种仪器，并展示通过使用它来监测猪模型在模拟出血和复苏过程中的节段腔室容积反应所获得的信息。这类信息在诊断和管理体液平衡的快速变化及各种临床治疗中可能具有重要价值。
