用于 SARS-CoV-2 感染的诊断方法。
Diagnostics for SARS-CoV-2 infections.
机构信息
Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
出版信息
Nat Mater. 2021 May;20(5):593-605. doi: 10.1038/s41563-020-00906-z. Epub 2021 Feb 15.
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every corner of the globe, causing societal instability. The resultant coronavirus disease 2019 (COVID-19) leads to fever, sore throat, cough, chest and muscle pain, dyspnoea, confusion, anosmia, ageusia and headache. These can progress to life-threatening respiratory insufficiency, also affecting the heart, kidney, liver and nervous systems. The diagnosis of SARS-CoV-2 infection is often confused with that of influenza and seasonal upper respiratory tract viral infections. Due to available treatment strategies and required containments, rapid diagnosis is mandated. This Review brings clarity to the rapidly growing body of available and in-development diagnostic tests, including nanomaterial-based tools. It serves as a resource guide for scientists, physicians, students and the public at large.
摘要
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）已传播到全球几乎每一个角落，导致社会不稳定。由此产生的 2019 年冠状病毒病（COVID-19）可导致发热、咽痛、咳嗽、胸痛和肌肉疼痛、呼吸困难、意识模糊、嗅觉丧失、味觉丧失和头痛。这些症状可进展为危及生命的呼吸功能不全，还可影响心脏、肾脏、肝脏和神经系统。SARS-CoV-2 感染的诊断常与流感和季节性上呼吸道病毒感染相混淆。由于现有的治疗策略和需要的控制措施，需要快速诊断。这篇综述为快速发展的现有和开发中的诊断检测方法提供了清晰的认识，包括基于纳米材料的工具。它为科学家、医生、学生和广大公众提供了资源指南。
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