Williams D A
Department of Statistics, University of Edinburgh, Scotland.
Biometrics. 1988 Mar;44(1):305-9.
Kupper et al. (1986, Biometrics 42, 85-98) considered the fitting of dose-response regressions to litter proportions in teratology experiments. They found that the estimators which maximise the beta-binomial likelihood become biased when the intralitter correlation is incorrectly assumed to be homogeneous. This paper considers the nature of this bias and its implications for the analysis of litter proportions in toxicology.
库珀等人（1986年，《生物统计学》42卷，85 - 98页）考虑了在致畸实验中剂量反应回归对窝仔比例的拟合。他们发现，当错误地假设窝内相关性是齐次的时候，最大化β - 二项式似然的估计量会产生偏差。本文探讨了这种偏差的性质及其对毒理学中窝仔比例分析的影响。
