Chen Yong, Liang Kung-Yee
Department of Biostatistics , Johns Hopkins University , 615 North Wolfe Street, Baltimore, Maryland 21205 , U.S.A.
Biometrika. 2010 Sep;97(3):603-620. doi: 10.1093/biomet/asq031. Epub 2010 Jun 11.
This paper considers the asymptotic distribution of the likelihood ratio statistic T for testing a subset of parameter of interest θ, θ = (γ, η), H(0) : γ = γ(0), based on the pseudolikelihood L(θ, ϕ̂), where ϕ̂ is a consistent estimator of ϕ, the nuisance parameter. We show that the asymptotic distribution of T under H(0) is a weighted sum of independent chi-squared variables. Some sufficient conditions are provided for the limiting distribution to be a chi-squared variable. When the true value of the parameter of interest, θ(0), or the true value of the nuisance parameter, ϕ(0), lies on the boundary of parameter space, the problem is shown to be asymptotically equivalent to the problem of testing the restricted mean of a multivariate normal distribution based on one observation from a multivariate normal distribution with misspecified covariance matrix, or from a mixture of multivariate normal distributions. A variety of examples are provided for which the limiting distributions of T may be mixtures of chi-squared variables. We conducted simulation studies to examine the performance of the likelihood ratio test statistics in variance component models and teratological experiments.
本文基于伪似然函数(L(θ, ϕ̂)),考虑用于检验感兴趣参数(θ)((θ = (γ, η)))的一个子集,即原假设(H(0) : γ = γ(0))时似然比统计量(T)的渐近分布,其中(ϕ̂)是干扰参数(ϕ)的一个相合估计。我们证明了在原假设(H(0))下(T)的渐近分布是独立卡方变量的加权和。给出了一些使极限分布为卡方变量的充分条件。当感兴趣参数的真值(θ(0))或干扰参数的真值(ϕ(0))位于参数空间的边界上时,该问题被证明渐近等价于基于来自具有错误指定协方差矩阵的多元正态分布或多元正态分布混合的一次观测来检验多元正态分布受限均值的问题。给出了各种示例,其中(T)的极限分布可能是卡方变量的混合。我们进行了模拟研究,以检验方差分量模型和致畸实验中似然比检验统计量的性能。