Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
Department of Pharmacy, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
Prostaglandins Other Lipid Mediat. 2021 Jun;154:106539. doi: 10.1016/j.prostaglandins.2021.106539. Epub 2021 Feb 14.
The World Health Organization has described the 2019 Coronavirus disease caused by an influenza-like virus called SARS-CoV-2 as a pandemic. Millions of people worldwide are already infected by this virus, and severe infection causes hyper inflammation, thus disrupting lung function, exacerbating breath difficulties, and death. Various inflammatory mediators bio-synthesized through the arachidonic acid pathway play roles in developing cytokine storms, injuring virus-infected cells. Since pro-inflammatory eicosanoids, including prostaglandins, and leukotrienes, are key brokers for physiological processes such as inflammation, fever, allergy, and pain but, their function in COVID-19 is not well defined. This study addresses eicosanoid's crucial role through the arachidonic pathway in inflammatory cascading and recommends using bioactive lipids, NSAIDs, steroids, cell phospholipase A2 (cPLA2) inhibitors, and specialized pro-resolving mediators (SPMs) to treat COVID-19 disease. The role of soluble epoxide hydrolase inhibitors (SEHIs) in promoting the activity of epoxyeicosatrienoic acids (EETs) and 17-hydroxide-docosahexaenoic acid (17-HDHA) is also discussed. Additional research that assesses the eicosanoid profile in COVID-19 patients or preclinical models generates novel insights into coronavirus-host interaction and inflammation regulation.
世界卫生组织将一种名为 SARS-CoV-2 的类似流感的病毒引起的 2019 年冠状病毒病描述为大流行。目前，全世界已有数百万人感染了这种病毒，严重的感染会导致过度炎症，从而破坏肺功能，加重呼吸困难，甚至导致死亡。通过花生四烯酸途径生物合成的各种炎症介质在细胞因子风暴的发展中发挥作用，从而损伤病毒感染的细胞。由于促炎类二十烷素（包括前列腺素和白三烯）是炎症、发热、过敏和疼痛等生理过程的关键介质，但它们在 COVID-19 中的功能尚未明确。本研究通过花生四烯酸途径探讨了类二十烷素在炎症级联反应中的关键作用，并建议使用生物活性脂质、非甾体抗炎药、类固醇、细胞磷酯酶 A2（cPLA2）抑制剂和特殊的促解决介质（SPM）来治疗 COVID-19 疾病。还讨论了可溶性环氧化物水解酶抑制剂（SEHIs）在促进环氧化物二十碳三烯酸（EETs）和 17-羟基二十二碳六烯酸（17-HDHA）活性方面的作用。评估 COVID-19 患者或临床前模型中类二十烷素谱的进一步研究为冠状病毒与宿主的相互作用和炎症调节提供了新的见解。
