Khan Mahmud Tareq Hassan, Ather Arjumand, Thompson Kenneth D, Gambari Roberto
Pharmacology Research Laboratory, Faculty of Pharmaceutical Sciences, University of Science and Technology Chittagong, Chittagong, Bangladesh.
Antiviral Res. 2005 Aug;67(2):107-19. doi: 10.1016/j.antiviral.2005.05.002.
Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection. Therefore, the discovery of novel anti-HSV drugs deserves great efforts. In this paper, we review anti-HSV substances from natural sources, including both extracts and pure compounds from herbal medicines, reported in studies from several laboratories. The role of traditional medicine for the development of anti-HSV compounds is also discussed. Interestingly, it was found that traditional medicines, like Ayurvedic, traditional Chinese (TCM), Chakma medicines, are good and potential sources for promising anti-HSV drugs. A second objective of this review is to discuss several anti-HSV compounds with respect to their structure-activity relationship (SAR). A large number of small molecules, like phenolics, polyphenols, terpenes (e.g., mono-, di-, tri-), flavonoids, sugar-containing compounds, were found to be promising anti-herpetic agents. Our major conclusion is that natural products from medicinal plant extracts are very important source of anti-HSV agents.
单纯疱疹病毒（HSV - 1和HSV - 2）是人类的重要病原体，对于高度易感的成年人而言尤其如此。此外，据报道HSV - 2是HIV感染的高危因素。因此，发现新型抗HSV药物值得付出巨大努力。在本文中，我们综述了来自多个实验室研究报道的天然来源的抗HSV物质，包括草药提取物和纯化合物。还讨论了传统医学在抗HSV化合物研发中的作用。有趣的是，发现阿育吠陀医学、传统中医（TCM）、查克马医学等传统医学是有前景的抗HSV药物的良好且潜在的来源。本综述的第二个目的是讨论几种抗HSV化合物的构效关系（SAR）。发现大量小分子，如酚类、多酚类、萜类（如单萜、二萜、三萜）、黄酮类、含糖化合物，是有前景的抗疱疹剂。我们的主要结论是药用植物提取物中的天然产物是抗HSV药物的非常重要的来源。
