Departmento de Microbioloxía e Parasitoloxía, Facultade de Bioloxía-CIBUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
Crit Rev Biotechnol. 2021 Jun;41(4):609-627. doi: 10.1080/07388551.2021.1873239. Epub 2021 Feb 16.
is a Gram positive spore-forming bacterial species of high biotechnological interest with numerous present and potential uses, including the production of bioactive compounds that are applied in a wide range of fields, such as aquaculture, agriculture, food, biomedicine, and pharmaceutical industries. Its use as an expression vector for the production of enzymes and other bioproducts is also gaining interest due to the availability of novel genetic manipulation tools. Furthermore, besides its widespread use as a probiotic, other biotechnological applications of strains include: bioflocculation, biomineralization, biofuel production, bioremediation, and anti-biofilm activity. Although authorities have approved the use of as a feed additive worldwide due to the absence of toxigenic potential, some probiotics containing this bacterium are considered unsafe due to the possible transference of antibiotic resistance genes. The wide variability in biological activities and genetic characteristics of this species makes it necessary to establish an exact protocol for describing the novel strains, in order to evaluate its biotechnological potential.
是一种革兰氏阳性产芽孢细菌,具有很高的生物技术应用价值,目前有许多潜在用途,包括生产生物活性化合物,这些化合物应用于广泛的领域,如水产养殖、农业、食品、生物医学和制药工业。由于新型遗传操作工具的出现,它作为生产酶和其他生物制品的表达载体也越来越受到关注。此外,除了作为益生菌的广泛应用外,菌株的其他生物技术应用还包括:生物絮凝、生物矿化、生物燃料生产、生物修复和抗生物膜活性。尽管由于缺乏毒力潜能,当局已批准在全球范围内将 作为饲料添加剂使用,但由于可能转移抗生素抗性基因,一些含有该细菌的益生菌被认为是不安全的。由于该物种的生物学活性和遗传特征存在广泛的可变性,因此有必要建立一个准确的描述新菌株的方案,以评估其生物技术潜力。