Sorbonne Université-INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France.
Institut Hospitalo-Universitaire ICAN, Paris, France.
Nat Commun. 2021 Feb 16;12(1):1064. doi: 10.1038/s41467-021-21308-y.
Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulate naturally all the reproductive and metabolic hallmarks of lean women with PCOS at puberty and in adulthood. The analysis of their gestation and of their fetuses demonstrates that this PCOS-like phenotype is developmentally programmed. GK rats also develop features of ovarian hyperstimulation syndrome. Lastly, a comparison between GK rats and a cohort of women with PCOS reveals a similar reproductive signature. Thus, this spontaneous rodent model of PCOS represents an original tool for the identification of the mechanisms involved in its pathogenesis and for the development of novel strategies for its treatment.
多囊卵巢综合征（PCOS）的特征是稀发排卵、高雄激素血症和多囊卵巢形态，同时伴有主要代谢紊乱。然而，尽管这种综合征的患病率很高，对人类和经济造成的影响也很大，但它的病因仍不清楚。在这项研究中，我们发现，2 型糖尿病模型 Goto-Kakizaki（GK）大鼠在青春期和成年期自然具有所有与瘦型 PCOS 女性相关的生殖和代谢特征。对其妊娠和胎儿的分析表明，这种 PCOS 样表型是发育性编程的。GK 大鼠还会出现卵巢过度刺激综合征的特征。最后，将 GK 大鼠与一组患有 PCOS 的女性进行比较，发现其具有相似的生殖特征。因此，这种自发性多囊卵巢综合征啮齿动物模型为鉴定其发病机制相关的机制以及为其治疗开发新策略提供了一个原始工具。
