可持续四组分环化反应合成 2,3,4,6-四芳基吡啶。
Sustainable Four-Component Annulation for the Synthesis of 2,3,4,6-Tetraarylpyridines.
机构信息
Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P R China.
School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P R China.
出版信息
J Org Chem. 2021 Mar 5;86(5):3897-3906. doi: 10.1021/acs.joc.0c02764. Epub 2021 Feb 17.
A one-pot, four-component annulation of 2,3,4,6-tetraarylpyridines from aromatic aldehydes, methyl ketones, diaryl ethanones, and ammonium acetate is described. The reaction features high functional group compatibility in air under solvent-free conditions without any additive and only water as the nontoxic byproduct, providing a strategy for the facile, economical, and eco-friendly construction of multiaryl-substituted pyridines from simple and readily available reactants.
本文描述了一种从芳香醛、甲基酮、二芳基乙酮和醋酸铵一锅、四组分合成 2,3,4,6-四芳基吡啶的方法。该反应在无溶剂、无添加剂、仅用水作为无毒副产物的条件下，具有很高的官能团兼容性，为从简单易得的原料高效、经济、环保地构建多芳基取代吡啶提供了一种策略。
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