两个欧洲睡眠中心的手动评分与基于人工智能的斯坦福-STAGES 算法的自动评分之间的睡眠分期评分者间可靠性。
Interrater sleep stage scoring reliability between manual scoring from two European sleep centers and automatic scoring performed by the artificial intelligence-based Stanford-STAGES algorithm.
机构信息
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Interdisciplinary Sleep Medicine Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
出版信息
J Clin Sleep Med. 2021 Jun 1;17(6):1237-1247. doi: 10.5664/jcsm.9174.
STUDY OBJECTIVES
The objective of this study was to evaluate interrater reliability between manual sleep stage scoring performed in 2 European sleep centers and automatic sleep stage scoring performed by the previously validated artificial intelligence-based Stanford-STAGES algorithm.
METHODS
Full night polysomnographies of 1,066 participants were included. Sleep stages were manually scored in Berlin and Innsbruck sleep centers and automatically scored with the Stanford-STAGES algorithm. For each participant, we compared (1) Innsbruck to Berlin scorings (INN vs BER); (2) Innsbruck to automatic scorings (INN vs AUTO); (3) Berlin to automatic scorings (BER vs AUTO); (4) epochs where scorers from Innsbruck and Berlin had consensus to automatic scoring (CONS vs AUTO); and (5) both Innsbruck and Berlin manual scorings (MAN) to the automatic ones (MAN vs AUTO). Interrater reliability was evaluated with several measures, including overall and sleep stage-specific Cohen's κ.
RESULTS
Overall agreement across participants was substantial for INN vs BER (κ = 0.66 ± 0.13), INN vs AUTO (κ = 0.68 ± 0.14), CONS vs AUTO (κ = 0.73 ± 0.14), and MAN vs AUTO (κ = 0.61 ± 0.14), and moderate for BER vs AUTO (κ = 0.55 ± 0.15). Human scorers had the highest disagreement for N1 sleep (κ = 0.40 ± 0.16 for INN vs BER). Automatic scoring had lowest agreement with manual scorings for N1 and N3 sleep (κ = 0.25 ± 0.14 and κ = 0.42 ± 0.32 for MAN vs AUTO).
CONCLUSIONS
Interrater reliability for sleep stage scoring between human scorers was in line with previous findings, and the algorithm achieved an overall substantial agreement with manual scoring. In this cohort, the Stanford-STAGES algorithm showed similar performances to the ones achieved in the original study, suggesting that it is generalizable to new cohorts. Before its integration in clinical practice, future independent studies should further evaluate it in other cohorts.
研究目的
本研究旨在评估在两个欧洲睡眠中心进行的手动睡眠分期评分与之前经过验证的基于人工智能的斯坦福-STAGES 算法的自动睡眠分期评分之间的评分者间可靠性。
方法
共纳入 1066 名参与者的整夜多导睡眠图。在柏林和因斯布鲁克睡眠中心进行手动睡眠分期评分，并使用斯坦福-STAGES 算法进行自动评分。对于每个参与者，我们比较了（1）因斯布鲁克与柏林评分（INN 与 BER）；（2）因斯布鲁克与自动评分（INN 与 AUTO）；（3）柏林与自动评分（BER 与 AUTO）；（4）因斯布鲁克和柏林评分者达成共识的自动评分（CONS 与 AUTO）；以及（5）因斯布鲁克和柏林的手动评分（MAN）与自动评分（MAN 与 AUTO）。采用多种措施评估评分者间可靠性，包括总体和睡眠分期特异性 Cohen's κ。
结果
参与者之间的整体一致性对于 INN 与 BER（κ=0.66±0.13）、INN 与 AUTO（κ=0.68±0.14）、CONS 与 AUTO（κ=0.73±0.14）和 MAN 与 AUTO（κ=0.61±0.14）均为高度一致，对于 BER 与 AUTO（κ=0.55±0.15）则为中度一致。人类评分者对 N1 睡眠的分歧最大（INN 与 BER 的 κ=0.40±0.16）。自动评分与手动评分的一致性最低，N1 和 N3 睡眠的 κ 值分别为 0.25±0.14 和 0.42±0.32（MAN 与 AUTO）。
结论
人类评分者之间的睡眠分期评分的评分者间可靠性与之前的研究结果一致，该算法与手动评分总体上具有高度一致性。在本队列中，斯坦福-STAGES 算法的表现与原始研究中的表现相似，表明它可以推广到新的队列。在将其整合到临床实践之前，未来的独立研究应在其他队列中进一步评估它。
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