[抗心律失常药物在缺血和高氧环境中的作用]
[Action of anti-arrhythmia agents in ischemia and hyperoxia].
作者信息
Kedrov S I, Reznikov K M, Leonov A N
出版信息
Farmakol Toksikol. 1988 Jan-Feb;51(1):41-4.
PMID:3360106
Abstract
During experiments (128 rabbits) it was shown that under ischemia and hyperoxia the pharmacodynamics of lidocaine, anaprilin and ethacizine changed in centrogenic and peripheral arrhythmias induced by aconitine. Hyperoxia significantly potentiated the antiarrhythmic effect of the drugs except lidocaine action in centrogenic arrhythmias.
摘要
在实验过程中（128只兔子）发现，在缺血和高氧条件下，利多卡因、心得安和乙胺碘呋酮在乌头碱诱发的中枢性和外周性心律失常中的药效学发生了变化。除利多卡因对中枢性心律失常的作用外，高氧显著增强了这些药物的抗心律失常作用。
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