Justice J, Paton D, Beyrer C R, Seddon G G
Arch Ophthalmol. 1977 Nov;95(11):2015-6. doi: 10.1001/archopht.1977.04450110109013.
Sodium fluorescein solutions, 3 ml of 25% solution and 5 ml of 10% solution, were compared with a double-blind crossover method in a group of 41 normal volunteers and in a group of 42 patients who had diverse ophthalmic disorders. Following injection of the solutions into the antecubital vein, visualization, serial fluorescein angiograms, and five-minute phase angiograms were studied and compared. The untoward reactions reported in both studies were of types usually associated with sodium fluorescein, the most common of which was a mild, transient nausea. On the basis of our results, there is no significant difference in the incidence and severity of adverse reactions between the 10% and 25% solutions. In the volunteer study, the 25% solution was significantly superior in visualization and paired comparison (P less than .001) in the patient study, the 25% solution was significantly superior in angiogram quality (P less than .01), five-minute phase angiogram (P less than .05), and paired comparison (P less than .005). The overall superiority of the 25% concentration in a 3-ml volume was demonstrated both subjectively and objectively in the volunteer study and in the patient study.
采用双盲交叉法，对41名正常志愿者和42名患有各种眼科疾病的患者进行了比较，比较了3毫升25%溶液和5毫升10%溶液的荧光素钠溶液。将溶液注入肘前静脉后，对显影情况、系列荧光素血管造影和五分钟期血管造影进行了研究和比较。两项研究中报告的不良反应均为通常与荧光素钠相关的类型，其中最常见的是轻度、短暂的恶心。根据我们的结果，10%溶液和25%溶液在不良反应的发生率和严重程度上没有显著差异。在志愿者研究中，25%溶液在显影和配对比较方面显著更优（P小于0.001）；在患者研究中，25%溶液在血管造影质量（P小于0.01）、五分钟期血管造影（P小于0.05）和配对比较（P小于0.005）方面显著更优。在志愿者研究和患者研究中，主观和客观上均证明了3毫升体积的25%浓度溶液总体上更具优势。
