Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Department of Systems Biology, Harvard Medical School, Boston, MA.
J Exp Med. 2021 Jan 4;218(1). doi: 10.1084/jem.20200264.
Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are emerging as an essential antitumor component based on their ability to foster T cell immunity and immunotherapy responses. Here, we discuss our expanding view of DC heterogeneity in human tumors, as revealed with meta-analysis of single-cell transcriptome profiling studies. We further examine tumor-infiltrating DC states that are conserved across patients, cancer types, and species and consider the fundamental and clinical relevance of these findings. Finally, we provide an outlook on research opportunities to further explore mechanisms governing tumor-infiltrating DC behavior and functions.
树突状细胞（DCs）在肿瘤微环境中只占很小的一部分，但基于其促进 T 细胞免疫和免疫治疗反应的能力，它们正逐渐成为一种重要的抗肿瘤成分。在这里，我们将通过对单细胞转录组分析研究的荟萃分析，讨论我们对人类肿瘤中 DC 异质性的不断扩大的认识。我们还进一步研究了跨患者、癌症类型和物种保守的肿瘤浸润性 DC 状态，并考虑了这些发现的基础和临床意义。最后，我们展望了研究机会，以进一步探索控制肿瘤浸润性 DC 行为和功能的机制。
