Department of Cardiology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, 323000 Zhejiang, China.
Biomed Res Int. 2021 Feb 1;2021:5948636. doi: 10.1155/2021/5948636. eCollection 2021.
The association between blood urea nitrogen (BUN) and prognosis has been the focus of recent research. Therefore, the objective of this study was to investigate the association between BUN and hospital mortality in critically ill patients with cardiogenic shock (CS). This was a retrospective cohort study, in which data were obtained from the Medical Information Mart for Intensive Care III V1.4 database. Data from 697 patients with CS were analyzed. Logistic regression and subgroup analyses were used to assess the association between BUN and hospital mortality in patients with CS. The average age of the 697 participants was 71.14 years, and approximately 42.18% were men. In the multivariate logistic regression model, after adjusting for age, sex, diabetes, cardiac arrhythmias, urine output, simplified acute physiology score II, sequential organ failure assessment, creatinine, anion gap, and heart rate, high BUN demonstrated strong associations with increased in-hospital mortality (per standard deviation increase: odds ratio [OR] 1.47, 95% confidence interval [CI] 1.13-1.92). A similar result was observed in BUN tertile groups (BUN 23-37 mg/dL versus 6-22 mg/dL: OR [95% CI], 1.42 [0.86-2.34]; BUN 38-165 mg/dL versus 6-22 mg/dL: OR [95% CI], 1.99 [1.10-3.62]; trend 0.0272). Subgroup analysis did not reveal any significant interactions among various subgroups, and higher BUN was associated with adverse clinical outcomes in patients with CS.
血尿素氮 (BUN) 与预后的关系一直是近期研究的焦点。因此，本研究旨在探讨危重症心源性休克 (CS) 患者 BUN 与院内死亡率的关系。这是一项回顾性队列研究，数据来自 Medical Information Mart for Intensive Care III V1.4 数据库。共分析了 697 例 CS 患者的数据。采用 logistic 回归和亚组分析评估 BUN 与 CS 患者院内死亡率的关系。697 名参与者的平均年龄为 71.14 岁，约 42.18%为男性。在多变量 logistic 回归模型中，调整年龄、性别、糖尿病、心律失常、尿量、简化急性生理学评分 II、序贯器官衰竭评估、肌酐、阴离子间隙和心率后，高 BUN 与住院死亡率增加呈强相关（每标准差增加：比值比 [OR] 1.47，95%置信区间 [CI] 1.13-1.92）。在 BUN 三分位组中也观察到了类似的结果（BUN 23-37mg/dL 与 6-22mg/dL 相比：OR[95%CI]，1.42[0.86-2.34]；BUN 38-165mg/dL 与 6-22mg/dL 相比：OR[95%CI]，1.99[1.10-3.62]；趋势 0.0272）。亚组分析未发现各亚组之间存在任何显著的交互作用，高 BUN 与 CS 患者的不良临床结局相关。
