Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No.106 Zhongshanerlu Street, Yuexiu District, Guangzhou, China.
Department of Otolaryngology-Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, China.
Sleep Breath. 2021 Dec;25(4):2163-2169. doi: 10.1007/s11325-021-02325-z. Epub 2021 Feb 18.
This study aimed to investigate pharyngeal paraesthesia symptoms in patients with obstructive sleep apnoea (OSA).
Patients with snoring and suspected OSA as well as age-matched controls were recruited. All participants underwent nocturnal polysomnography (PSG) and pharyngeal paraesthesia assessment using the Glasgow-Edinburgh throat scale (GETS). The incidence and severity of pharyngeal paraesthesia symptoms were compared between the groups.
A total of 280 patients who snored or were suspected of having OSA and 35 healthy, age-matched controls were recruited. The total pharyngeal paraesthesia symptom score was significantly higher in the OSA group than in the healthy group (12 [5, 23] vs. 3 [0, 9]; p < 0.001). The most frequent pharyngeal paraesthesia symptoms in the snore patients were Q7 (catarrh down the throat) and Q3 (discomfort/irritation in the throat), which are related to the irritability of the throat. The incidence of Q7 (OSA, 58% vs. controls, 14%; χ = 23.66; p < 0.001), Q3 (OSA, 46% vs. controls, 3%; χ = 23.07; p < 0.001), Q1 (feeling of something stuck in the throat; OSA, 33% vs. controls, 6%; χ = 11.00; p = 0.001), Q6 (swelling in the throat; OSA, 31% vs. controls, 0%; χ = 14.53; p < 0.001), Q9 (want to swallow all the time; OSA, 20% vs. controls, 6%; χ = 6.28; p = 0.012), Q5 (throat closing off; OSA, 24% vs. controls, 6%; χ = 6.16; p = 0.013), and Q2 (pain in the throat; OSA, 23% vs. controls, 6%; χ = 5.32; p = 0.021) was significantly higher in the OSA group than in the controls CONCLUSIONS: Patients with obstructive sleep apnoea have higher pharyngeal paraesthesia symptoms scores and tend to have irritated throats compared to healthy controls.
ClinicalTrials.gov identifier: NCT03506178.
本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）患者的咽部感觉异常症状。
招募了打鼾和疑似 OSA 的患者以及年龄匹配的对照组。所有参与者均接受了夜间多导睡眠图（PSG）和咽部感觉异常评估，使用格拉斯哥-爱丁堡咽喉量表（GETS）。比较了各组之间咽部感觉异常症状的发生率和严重程度。
共招募了 280 名打鼾或疑似 OSA 的患者和 35 名健康、年龄匹配的对照组。OSA 组的总咽部感觉异常症状评分明显高于健康组（12 [5，23] vs. 3 [0，9]；p < 0.001）。打鼾患者最常见的咽部感觉异常症状是 Q7（喉咙有痰）和 Q3（喉咙不适/刺激），这与喉咙的易激惹有关。Q7（OSA，58% vs. 对照组，14%；χ²=23.66；p<0.001）、Q3（OSA，46% vs. 对照组，3%；χ²=23.07；p<0.001）、Q1（感觉有东西卡在喉咙里；OSA，33% vs. 对照组，6%；χ²=11.00；p=0.001）、Q6（喉咙肿胀；OSA，31% vs. 对照组，0%；χ²=14.53；p<0.001）、Q9（一直想吞咽；OSA，20% vs. 对照组，6%；χ²=6.28；p=0.012）和 Q5（喉咙关闭；OSA，24% vs. 对照组，6%；χ²=6.16；p=0.013）的发生率在 OSA 组明显高于对照组。
与健康对照组相比，阻塞性睡眠呼吸暂停患者的咽部感觉异常症状评分较高，且往往有喉咙刺激感。
ClinicalTrials.gov 标识符：NCT03506178。
