Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
J Med Virol. 2021 Jul;93(7):4167-4181. doi: 10.1002/jmv.26891. Epub 2021 Apr 1.
A more detailed understanding of Treg cells in COVID-19 infection will broaden our knowledge of the COVID-19 immunopathology and give us more insight into the curative immune-based strategies. We systematically searched electronic databases (PubMed, Google Scholar, EMBASE) and identified 18 eligible studies. Despite the inconsistencies between the results, we observed a trend toward decreasing Treg levels in severe COVID-19 patients. This finding underlines the hypothesis that Tregs play a role in the pathogenesis of COVID-19. Further studies on Tregs' functional aspects are necessary to illustrate Tregs' potential role in COVID-19 disease.
更详细地了解 COVID-19 感染中的 Treg 细胞将拓宽我们对 COVID-19 免疫病理学的认识，并使我们更深入地了解基于免疫的治疗策略。我们系统地检索了电子数据库（PubMed、Google Scholar、EMBASE），并确定了 18 项符合条件的研究。尽管结果存在差异，但我们观察到严重 COVID-19 患者的 Treg 水平呈下降趋势。这一发现支持了 Tregs 在 COVID-19 发病机制中起作用的假说。进一步研究 Tregs 的功能方面对于阐明 Tregs 在 COVID-19 疾病中的潜在作用是必要的。
