Scientist C, Division of Basic Medical Sciences, Indian Council of Medical Research, New Delhi - 110029, India.
Department of Neurological Surgery, Washington University School of Medicine, St. Louis-63110, Missouri, USA.
Comb Chem High Throughput Screen. 2022;25(10):1601-1618. doi: 10.2174/1386207324666210219103430.
The use of plants and plant products in health care has shown an exponential increase in the past two decades.
In-spite of the availability of well-established pharmacotherapy for epilepsy, a large no of the population still explores alternative treatments due to refractory seizures, adverse effects of drugs, chronic treatment, inaccessibility of standard therapies in rural areas and the social stigma attached to the disease. Various studies on medicinal plants showed the protective effect of herbals in animal models of epilepsy.
In the present review, a status analysis of the traditional use of various medicinal plants in epilepsy with a special focus on plats having anti-inflammatory potential is recorded.
The shortcomings of research on medicinal plants which need to be explored further in order to tackle the growing need for safer and effective drugs for epilepsy are discussed. Overall, there is a huge scope of herbal drugs in CNS disorders, especially epilepsy, either as an adjunct by reducing the dose and thus side effects of standard anti-epileptic drugs or as a standalone agent. Although, there is still an urgent need of well planned randomized controlled clinical trials to validate their efficacy and safety.
在过去的二十年中，植物和植物产品在医疗保健中的应用呈指数级增长。
尽管癫痫有成熟的药物治疗方法，但由于难治性发作、药物副作用、慢性治疗、农村地区无法获得标准治疗以及疾病带来的社会耻辱感，许多人仍在探索替代疗法。各种关于药用植物的研究表明，草药在癫痫动物模型中具有保护作用。
在本综述中，记录了各种药用植物在癫痫中的传统用途的现状分析，特别关注具有抗炎潜力的植物。
讨论了药用植物研究中需要进一步探索的不足之处，以满足对更安全有效的癫痫药物日益增长的需求。总的来说，草药在中枢神经系统疾病，特别是癫痫方面有很大的应用潜力，无论是作为辅助治疗，减少标准抗癫痫药物的剂量和因此减少副作用，还是作为单一药物。尽管如此，仍然迫切需要进行精心设计的随机对照临床试验来验证其疗效和安全性。
