内吞作用调节和组织受体信号的机制。
Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis.
机构信息
Department of Psychiatry, University of California, San Francisco, California 94143, USA; email:
Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA; email:
出版信息
Annu Rev Biochem. 2021 Jun 20;90:709-737. doi: 10.1146/annurev-biochem-081820-092427. Epub 2021 Feb 19.
Abstract
Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40 years ago through the study of tyrosine kinase growth factor receptors, are now known to exist for multiple receptor classes and to affect myriad physiological and developmental processes. This review summarizes our present understanding of how endocytosis orchestrates cellular signaling networks, with an emphasis on mechanistic underpinnings and focusing on two receptor classes-tyrosine kinase and G protein-coupled receptors-that have been investigated in particular detail. Together, these examples provide a useful survey of the current consensus, uncertainties, and controversies in this rapidly advancing area of cell biology.
摘要
内吞作用与细胞信号之间的复杂关系早在近 40 年前通过对酪氨酸激酶生长因子受体的研究就已被认识到，现在已知其存在于多种受体类别中，并影响众多生理和发育过程。本综述总结了我们目前对内吞作用如何协调细胞信号网络的理解，重点介绍了机制基础，并特别关注了两类受体——酪氨酸激酶和 G 蛋白偶联受体——这些受体已经被特别详细地研究过。这些例子共同提供了对细胞生物学这一快速发展领域的当前共识、不确定性和争议的有用调查。
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