Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Tongzipo Road, Changsha, 410013, Hunan, China.
Hunan Key Laboratory of Non-Resolving Inflammation and Cancer, Xiangya Road, Changsha, 410008, Hunan, China.
Dig Dis Sci. 2022 Jan;67(1):56-66. doi: 10.1007/s10620-021-06831-8. Epub 2021 Feb 20.
Inflammatory bowel disease (IBD) is a chronic and nonspecific intestinal inflammatory condition with high relapse rate. Its pathogenesis has been linked to dysbacteriosis, genetic and environmental factors. In recent years, a new type of lymphocytes, termed innate lymphoid cells, has been described and classified into three subtypes of innate lymphoid cells-group 1, group 2 and group 3. An imbalance among these subsets' interaction with gut microbiome, and other immune cells affects intestinal mucosal homeostasis. Understanding the role of innate lymphoid cells may provide ideas for developing novel and targeted approaches for treatment of IBD.
炎症性肠病（IBD）是一种慢性、非特异性的肠道炎症性疾病，具有较高的复发率。其发病机制与肠道菌群失调、遗传和环境因素有关。近年来，一种新型淋巴细胞，即固有淋巴细胞，已被描述并分为固有淋巴细胞 1 型、2 型和 3 型。这些亚群与肠道微生物群和其他免疫细胞相互作用的失衡会影响肠道黏膜的稳态。了解固有淋巴细胞的作用可能为开发治疗 IBD 的新的靶向方法提供思路。
