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用于癌症治疗的基于纳米颗粒的药物递送系统。

Nanoparticle-based drug delivery systems for cancer therapy.

作者信息

Dang Yu, Guan Jianjun

机构信息

Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, 63130, USA.

出版信息

Smart Mater Med. 2020;1:10-19. doi: 10.1016/j.smaim.2020.04.001. Epub 2020 Apr 13.

DOI:10.1016/j.smaim.2020.04.001
PMID:34553138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8455119/
Abstract

Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life of vulnerable drugs and proteins, 2) improving the solubility of hydrophobic drugs, and 3) allowing controlled and targeted release of drugs in diseased site. This review mainly focuses on nanoparticle-based DDS fabricated from chitosan, silica, and poly (lactic-co-glycolic acid). Their fabrication methods and applications in cancer treatment are introduced. The current limitations and future perspectives of the nanoparticle-based DDS are discussed.

摘要

基于纳米颗粒的药物递送系统（DDS）被认为在癌症治疗方面具有广阔前景。与传统的药物递送系统相比，基于纳米颗粒的药物递送系统通过以下方式提高了疗效：1）延长易降解药物和蛋白质的半衰期；2）提高疏水性药物的溶解度；3）实现药物在病变部位的可控靶向释放。本综述主要聚焦于由壳聚糖、二氧化硅和聚（乳酸-乙醇酸）制备的基于纳米颗粒的药物递送系统。介绍了它们的制备方法及其在癌症治疗中的应用。并讨论了基于纳米颗粒的药物递送系统目前的局限性和未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/a14951153449/nihms-1631131-f0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/4371edcf947f/nihms-1631131-f0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/26d8d86eca33/nihms-1631131-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/a14951153449/nihms-1631131-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/39066ccfc596/nihms-1631131-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/da4d5c20219e/nihms-1631131-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/736bf266c082/nihms-1631131-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/03e3694ed086/nihms-1631131-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/4371edcf947f/nihms-1631131-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/7a8e960274d0/nihms-1631131-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/26d8d86eca33/nihms-1631131-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b8e/8455119/a14951153449/nihms-1631131-f0008.jpg

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