Cemerikić B, Genbacev O, Sulović V, Beaconsfield R
Institute of Endocrinology, Immunology and Nutrition - INEP, Zemun, Yugoslavia.
Life Sci. 1988;42(18):1773-9. doi: 10.1016/0024-3205(88)90044-6.
Opiate synthesis by human placental cells and the presence of kappa-type opiate binding sites in the syncytiotrophoblast brush border membrane may indicate the possible role of morphine-like substances in the autocrine regulation of trophoblast cell metabolism. This study was undertaken to examine the in vitro effect of morphine on hCG (human chorionic gonadotrophin) and hPL (human placental lactogen) release by 1st and 3rd trimester placental tissue explants. The results have shown that morphine (100 nM) significantly stimulated hCG secretion by 6-8 weeks old trophoblast and was without effect on hPL. Hormone secretion by term placental tissue explants was unaffected by morphine treatment. Based on these results we assume that opiates may have a role in the local (autocrine and/or paracrine) regulation of hCG secretion in early gestation.
人胎盘细胞合成阿片类物质以及合体滋养层刷状缘膜中存在κ型阿片类结合位点，这可能表明吗啡样物质在滋养层细胞代谢的自分泌调节中具有潜在作用。本研究旨在检测吗啡对孕早期和孕晚期胎盘组织外植体释放人绒毛膜促性腺激素（hCG）和人胎盘催乳素（hPL）的体外作用。结果显示，吗啡（100 nM）显著刺激6 - 8周龄滋养层细胞分泌hCG，而对hPL无影响。足月胎盘组织外植体的激素分泌不受吗啡处理的影响。基于这些结果，我们推测阿片类物质可能在妊娠早期hCG分泌的局部（自分泌和/或旁分泌）调节中发挥作用。
