Department of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Department of Surgery, Oklahoma Health Science Center, Oklahoma City, 73104, USA.
Sci Rep. 2021 Feb 23;11(1):4366. doi: 10.1038/s41598-021-83658-3.
Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.
光声成像是一种新的生物医学成像技术，与传统的光学成象和超声相比具有明显的优势。虽然该成像技术自最初发展以来已经得到了改进，但专门用于光声成象的造影剂的开发一直停滞不前。目前对造影剂的探索仅限于已经在光学成像应用中确立的标准商业染料。虽然这些化合物中的一些已经证明在光声成象中有应用价值，但它们远非最佳选择，需要具有定制光声性能的造影剂。本文报道了光声造影剂的合成、封装在肿瘤靶向硅纳米粒子中以及在体内肿瘤光声成像中的应用。
