Orji M O, Osinaike B B, Amanor-Boadu S D, Ugheoke A
Department of Anaesthesia, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Anaesthesia, University College Hospital, Ibadan, Nigeria.
Ann Ib Postgrad Med. 2020 Jun;18(1):3-8.
Sore throat is a common post-operative complaint which can cause significant distress and morbidity. We tested and compared the efficacy of nebulized Magnesium and Ketamine on the incidence and severity of sore throat within the first 24 hours after general anaesthesia.
To compare the incidence and severity of post-operative sore throat at 2, 4, 8, 12 and 24 hours after extubation following pre-induction administration of nebulized Magnesium and Ketamine.
In this randomized controlled trial, 99 adult ASA I and II patients between the ages of 16 - 65 years were administered nebulized Ketamine 50 mg, Magnesium Sulphate 250 mg or saline for ten minutes prior to induction of general anaesthesia and orotracheal intubation. Incidence and severity of post-operative sore throat were assessed at 2, 4, 8, 12 and 24 hours post extubation.
The incidence of sore throat at 4, 8, 12 and 24 hours post tracheal extubation were significantly lower in the Magnesium (18.2%, 12.1%, 0, 0; p = 0.009, 0.006, ≤0.0001, 0.003) and Ketamine group (24.2%, 12.1%, 6.1%, 0; p = 0.041, 0.006, 0.001, 0.003) compared with the saline group (48.5%, 42.4%, 39.4%, 24.2%). Patients also had significantly less severe sore throat at 4 and 8 hours post extubation in both Magnesium and Ketamine groups (p = 0.0 11, 0.041).
Pre-induction nebulization of Ketamine or Magnesium can decrease the incidence and severity of sore throat in the first 24 hours after anaesthesia.
咽喉痛是常见的术后主诉，可导致明显不适和发病。我们测试并比较了雾化镁和氯胺酮对全身麻醉后24小时内咽喉痛的发生率和严重程度的影响。
比较诱导前雾化镁和氯胺酮后拔管2、4、8、12和24小时后术后咽喉痛的发生率和严重程度。
在这项随机对照试验中，99例年龄在16 - 65岁之间的成年ASA I和II级患者在全身麻醉诱导和经口气管插管前10分钟接受雾化氯胺酮50毫克、硫酸镁250毫克或生理盐水。在拔管后2、4、8、12和24小时评估术后咽喉痛的发生率和严重程度。
与生理盐水组（48.5%、42.4%、39.4%、24.2%）相比，镁组（18.2%、12.1%、0、0；p = 0.009、0.006、≤0.0001、0.003）和氯胺酮组（24.2%、12.1%、6.1%、0；p = 0.041、0.006、0.001、0.003）气管拔管后4、8、12和24小时咽喉痛的发生率显著降低。镁组和氯胺酮组患者在拔管后4和8小时咽喉痛的严重程度也显著减轻（p = 0.011、0.041）。
诱导前雾化氯胺酮或镁可降低麻醉后24小时内咽喉痛的发生率和严重程度。
