Brown R G, MacCarthy B, Gotham A M, Der G J, Marsden C D
Department of Neurology, Institute of Psychiatry, De Crespigny Park, London.
Psychol Med. 1988 Feb;18(1):49-55. doi: 10.1017/s0033291700001872.
Patients with Parkinson's disease, 132 in number, were followed up after approximately one year, and measures of depression and disability re-administered. Depression was common on both occasions, and was characterized by dysphoria, pessimism and somatic symptoms, but not guilt or self-blame. Depression and disability were associated on both occasions. The relationship between changes in disability and depression across time was complex. In trying to understand changes in depression, the absolute change in disability may be less important than the relative change and rate of change. The results were discussed in relation to findings from other disease groups, and the implications for the clinical management of depression in Parkinson's disease.
132名帕金森病患者在大约一年后接受了随访，并再次进行了抑郁和残疾程度测量。两次测量时抑郁都很常见，其特征为烦躁不安、悲观情绪和躯体症状，但没有内疚或自责。两次测量时抑郁与残疾都有关联。残疾变化与抑郁随时间的关系很复杂。在试图理解抑郁的变化时，残疾的绝对变化可能不如相对变化和变化率重要。结合其他疾病组的研究结果对这些结果进行了讨论，并探讨了其对帕金森病抑郁临床管理的意义。
