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全国卵巢癌女性患者接受积极临终关怀的趋势和种族差异。

Trends and racial disparities in aggressive end-of-life care for a national sample of women with ovarian cancer.

机构信息

Center for Improving Patient and Population Health and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.

Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan.

出版信息

Cancer. 2021 Jul 1;127(13):2229-2237. doi: 10.1002/cncr.33488. Epub 2021 Feb 25.

Abstract

BACKGROUND

The clinical landscape has moved toward less aggressive end-of-life care for women with ovarian cancer. However, whether there has been a decline in the use of aggressive end-of-life services is unknown. The authors evaluated current national trends and racial disparities in end-of-life care among women with ovarian cancer using the Surveillance, Epidemiology, and End Results-Medicare-linked data set.

METHODS

In total, 7756 Medicare beneficiaries aged >66 years with ovarian cancer who died between 2007 and 2016 were identified. The authors examined trends and racial disparities in late hospice or no hospice use, >1 emergency department (ED) visit, intensive care unit admission, >1 hospitalization, terminal hospitalization, chemotherapy, and invasive and/or life-extending procedures using multivariable logistic regression.

RESULTS

The median hospice length of stay did not change over time; however, women were increasingly admitted to the intensive care unit and had multiple ED visits in the last month of life (P < .001). Not enrolling in hospice at the end of life and terminal hospitalizations decreased over time (P < .001). Non-White women were more likely to receive aggressive end-of-life care, particularly for hospital-related utilization and life-extending procedures, whereas non-Hispanic Black women were more likely to have >1 ED visit (odds ratio, 2.04; 95% CI, 1.57-2.64) or life-extending procedures (odds ratio, 1.89; 95% CI, 1.45-2.48) compared with non-Hispanic White women.

CONCLUSIONS

Despite clinical guidelines and increasing emphasis on reducing aggressive end-of-life care, the use of aggressive end-of-life care for women with ovarian cancer persists, and care is most aggressive for non-White women.

摘要

背景

临床治疗模式已逐渐减少对卵巢癌女性的激进临终关怀。然而,目前尚不清楚激进临终服务的使用是否有所减少。作者使用监测、流行病学和最终结果-医疗保险链接数据集评估了卵巢癌女性临终关怀的当前国家趋势和种族差异。

方法

共确定了 7756 名年龄>66 岁、2007 年至 2016 年期间死于卵巢癌的 Medicare 受益患者。作者使用多变量逻辑回归分析了晚期临终关怀或无临终关怀、>1 次急诊就诊、入住重症监护病房、>1 次住院、临终住院、化疗以及侵袭性和/或延长生命程序的趋势和种族差异。

结果

临终关怀的中位住院时间没有随时间变化;然而,女性在生命的最后一个月越来越多地入住重症监护病房,且多次急诊就诊(P<0.001)。临终时不参加临终关怀和终末期住院的情况随时间减少(P<0.001)。非白人女性更有可能接受激进的临终关怀,特别是在与医院相关的利用和延长生命的程序方面,而非西班牙裔黑人女性更有可能进行>1 次急诊就诊(比值比,2.04;95%置信区间,1.57-2.64)或接受延长生命的程序(比值比,1.89;95%置信区间,1.45-2.48)比非西班牙裔白人女性。

结论

尽管有临床指南和越来越重视减少激进的临终关怀,但卵巢癌女性的激进临终关怀的使用仍然存在,并且非白人女性的护理最为激进。

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