Department of Epidemiology, University of Washington, Seattle, WA, USA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Public Health, Seattle & King County, Seattle, WA, USA.
Vaccine. 2021 Mar 19;39(12):1765-1772. doi: 10.1016/j.vaccine.2021.02.006. Epub 2021 Feb 25.
The aim of this study was to measure the effect of a multicomponent human papillomavirus (HPV) vaccine promotion campaign on adolescent HPV vaccine uptake at school-based health centers (SBHCs) in Seattle, WA.
Youth-led HPV vaccine promotion campaigns were introduced in 2016 in 13 schools with SBHCs in Seattle. Five other schools with SBHCs served as controls. Vaccination records for students were obtained from the Washington Immunization Information System from September 2012 to August 2018. We compared increase in HPV vaccine uptake in SBHCs between 1) intervention and control schools, and 2) pre- and post-intervention periods in intervention schools using generalized estimating equations.
HPV vaccine uptake was high at baseline among students that use SBHCs for vaccines and has steadily increased between 2012 and 2018. Implementing the promotion campaign resulted in 14% higher (95% Confidence Interval (CI): 1%, 30%) HPV vaccine uptake in intervention SBHCs compared to control SBHCs, adjusting for time and confounders. Comparing pre-and post-intervention periods in intervention SBHCs, HPV vaccine uptake was 14% higher (95% CI: -4%, 35%) in the post-intervention period. SBHCs that received more active intervention activities saw 9% higher (95% CI: 1%, 21%) vaccine uptake compared to those that received passive intervention.
The vaccination promotion program implemented in a school-based setting resulted in higher HPV vaccine uptake in the post-intervention period compared to pre-intervention period, but this increase was not statistically significant. Even so, schools that received more intervention activities for longer periods of time had higher HPV vaccine uptake.
本研究旨在衡量在西雅图的学校保健中心（SBHC）开展多价人乳头瘤病毒（HPV）疫苗推广活动对青少年 HPV 疫苗接种率的影响。
2016 年，在西雅图的 13 所设有 SBHC 的学校中引入了由青少年主导的 HPV 疫苗推广活动。另外 5 所设有 SBHC 的学校作为对照组。从 2012 年 9 月至 2018 年 8 月，从华盛顿免疫信息系统中获取了学生的疫苗接种记录。我们使用广义估计方程比较了 1）干预组和对照组 SBHC 之间以及 2）干预组干预前后的 HPV 疫苗接种率的增加情况。
在基线时，使用 SBHC 接种疫苗的学生的 HPV 疫苗接种率较高，并且在 2012 年至 2018 年间稳步上升。实施推广活动后，与对照组 SBHC 相比，干预组 SBHC 的 HPV 疫苗接种率提高了 14%（95%置信区间：1%，30%），同时调整了时间和混杂因素。在干预组 SBHC 中比较干预前后的时间段，干预后 HPV 疫苗接种率提高了 14%（95%置信区间：-4%，35%）。与接受被动干预的 SBHC 相比，接受更积极干预活动的 SBHC 的疫苗接种率提高了 9%（95%置信区间：1%，21%）。
在学校环境中实施的疫苗接种推广计划在干预后时期比干预前时期的 HPV 疫苗接种率更高，但这种增加没有统计学意义。即便如此，接受干预活动时间更长的学校的 HPV 疫苗接种率更高。
